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March 2012

Autism mutations lead to scores of symptoms in rodents

by  /  14 March 2012

Mutations in more than 100 autism-associated genes lead to shared neurobiological deficits in mice, including alterations in the shape of their brains and changes to the electrical properties of neurons, according to a study published 20 February in Molecular Autism.

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Fruit fly reference helps link genes to traits

by  /  7 March 2012

Researchers have generated and sequenced almost 200 different strains of fruit flies, a widely used model organism, according to a study published 8 February in Nature. The resource they created, called the Drosophila Genetic Reference Panel, will enable researchers to link genetic variants with aspects of fly biology and behavior.

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February 2012

MRI devices for children reduce head motion in scanner

by  /  29 February 2012

Researchers have developed functional magnetic imaging devices that are optimized to fit children’s heads, according to a study published in the December issue of Magnetic Resonance in Medicine. These tools increase the quality of the data and deter head motion, which research suggests can lead to spurious results.

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Study charts methylation patterns in developing brain

by  /  22 February 2012

Researchers have charted patterns of DNA methylation — a chemical alteration to DNA that modifies gene expression — in the planning center of the brain from before birth to old age. The results were published 10 February in The American Journal of Human Genetics.

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Researchers chart 3D structure of fruit fly chromosomes

by  /  15 February 2012

A new study reveals the three-dimensional structure of fruit fly chromosomes, which groups together active and inactive genes. The results were published 3 February in Cell.

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Microscope reveals nanoscale detail in live mouse brains

by  /  8 February 2012

A new microscope allows researchers to capture the movement of tiny signal-receiving branches in the brains of adult mice at the nanoscale level. The results were published 3 February in Science.

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New machine takes rapid, reliable pictures of brains

by  /  1 February 2012

An automated instrument can reconstruct fluorescently labeled mouse brains in less than a day, researchers reported 15 January in Nature Methods.

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January 2012

New technique charts patterns of microRNA expression

by  /  25 January 2012

Researchers have mapped the levels of tiny RNA fragments that regulate gene expression in specific brain regions and subtypes of neurons. The results were published 12 January in Neuron.  

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New resource compiles data on autism-linked genes

by  /  18 January 2012

A new online database provides searchable information for nearly 10,000 genes, variants and chromosomal regions linked to autism. Researchers describe the resource, dubbed AutismKB, in the January issue of Nucleic Acids Research.

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Video technique measures monkeys’ social interest

by  /  11 January 2012

Male rhesus macaques show more interest in videos with social content, such as another monkey displaying aggression, than in videos of landscapes or other animals, according to a study published 26 October in PLoS One.

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