Activating the immune system blunts social behavior in mice missing a copy of the autism-linked gene SHANK3, according to a new study. Blocking TRPV4, which encodes an ion channel involved in inflammatory responses, can reverse this effect.
Spectrum: Autism Research News
Mutations in all three accelerate the maturation of inhibitory neurons, which could upset the brain’s balance of excitation and inhibition early in development.
The paper relied on parent-reported data and adjusted for few potentially confounding variables.
A basic scientist at heart, Hollis Cline has spent decades pushing the boundaries of what researchers can see in the brain. Her persistence has led to a deeper understanding of how some autism-linked genes influence brain development.
The protein, FMRP, shapes cell signaling near synapses but switches to regulate genes in the cell body, according to new research.
A researcher and science officer give tips for getting started with grant writing; scientists on Twitter explain why they went tenure-track; and a neurobiologist discusses why the field’s next generation needs to learn to code.
This week’s Community Newsletter takes up tweets about how often autism intervention research fails to report participants’ race and ethnicity, benchmarks for effect sizes and mapping chandelier cells in the mouse visual cortex.
Here is a roundup of news and research for the week of 24 January.
Some copy number variants may boost a person’s chances of having autism, but to a lesser extent than previously thought.
The current system to approve genetic and metabolic conditions for newborn screening can’t keep pace with research on new therapies. Don Bailey wants to bring it up to speed.