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Tag: brain size

September 2021
Four brains showing areas affected by the X chomosome in yellow

X chromosome exerts extra influence on brain development

by  /  15 September 2021

The X chromosome holds stronger-than-expected genetic sway over the structure of several brain regions. The genes that may underlie this oversized influence have ties to autism.

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Colorful illustration shows a esearcher with frogs and frog eggs.

Autism research makes the leap to frogs

by  /  8 September 2021

Frogs are useful for autism research for a slew of reasons, including the fact that the animals’ initial development occurs outside of the mother’s body in plain view.

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neurons in organoids

Protein inhibitor normalizes neuronal migration in organoid model of autism

by  /  1 September 2021

Inhibiting a protein that helps cells move or change shape prevents atypical neuronal migration in 3D clusters of brain cells carrying autism-linked genetic variants.

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August 2021
Holly Stessman standing in her garden looking up and holding her two chickens.

Beyond the Bench: A conversation with Holly Stessman

by  /  13 August 2021

When Holly Stessman isn’t probing autism genes, she is tending to her flock of chickens or seeking out the next great sci-fi movie.

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May 2021
Microglia activity seen in red, green and blue.

Autism mutation may cause big brain via ‘don’t eat me’ signals

by  /  17 May 2021

An autism-linked mutation could make the brain grow unusually large by prompting cells to express a chemical signal better known for its connection to cancer.

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April 2021
Two views of mouse brain slices colorized in green and red.

Jump-starting growth signaling reverses microcephaly in autism mouse model

by  /  29 April 2021

A genetic therapy and an existing drug both restore typical brain size in mice missing DYRK1A, a top autism candidate gene, in the cerebral cortex, a new study shows. The animals typically have smaller brains than controls.

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Loss of CHD8 from cerebellum disrupts movements, not social behaviors

by  /  26 April 2021

Deleting the autism-linked gene CHD8 from specific cells in the cerebellum, a brain region important for movement, leads to motor deficits but does not alter social behaviors in mice.

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March 2021
Oligodendrocyte shown orange on black in this scanning electron micrograph.

How oligodendrocytes may shape autism

by  /  15 March 2021

A growing body of evidence shows that brain cells called oligodendrocytes may play a larger role in autism than previously thought.

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January 2021
Colorful CT scan of a zebrafish head.

Zebrafish strains reveal broad effects of autism genes

by  /  11 January 2021

Mutations in autism-linked genes lead to a variety of changes in brain activity, sensory perception and sleep-wake cycles in zebrafish.

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December 2020
Brain organoid with multiple stains; red and green, to indicate cells.

New method probes genes’ function in brain organoids

by  /  16 December 2020

A screening technique tests how inactivated genes affect spheres of cultured brain cells; it could shed light on autism-linked mutations.

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