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Tag: CHD8

September 2021
researcher holds zebrafinch

Fish, frogs, flies and other fauna in scientific firsts

by  /  8 September 2021

Over the past century, scientists have used a variety of animal models to advance their understanding of the developing brain and autism.

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August 2021
Illustration of brain showing overexcited and underexcited parts of the brain represented by jagged and loose squiggles.

Disruptions to brain’s ‘thermostat’ may underpin autism traits

by  /  18 August 2021

Mounting evidence suggests that autism often involves upsets in homeostatic plasticity, a set of processes neurons use to stabilize their activity. These disruptions result from a range of autism-linked mutations and may help to explain the condition’s famed heterogeneity.

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July 2021

Sleep problems in autism may stem from leaky brain barrier

by  /  23 July 2021

Problems with falling and staying asleep are common in autism, and they may be due in part to leaks in the blood-brain barrier, according to a new study in fruit flies.

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Illustration shows yellow landscape with blue sections and a lot of trains on paths with kids on the trains, going different directions.

Mapping the futures of autistic children

by  /  14 July 2021

Researchers can roughly project what autistic children’s lives will look like years down the road. But how good is their crystal ball — and what are its benefits?

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May 2021
Mouse gut cells in blue, purple and pink

Loss of top autism-linked gene from gut alters behavior in mice

by  /  4 May 2021

Deleting CHD8 from the intestines induces gastrointestinal and behavioral changes in mice that resemble traits in people with mutations in the gene.

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April 2021
Female mouse with its litter of pups.

Few autism researchers control for the ‘litter effect’ — this needs to change

by ,  /  27 April 2021

Anyone who uses multiple animals from a small number of litters to increase sample size is making a serious mistake. The similarities within individual litters will heavily skew the results.

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Loss of CHD8 from cerebellum disrupts movements, not social behaviors

by  /  26 April 2021

Deleting the autism-linked gene CHD8 from specific cells in the cerebellum, a brain region important for movement, leads to motor deficits but does not alter social behaviors in mice.

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March 2021
Genetic sequencing on computer screen in lab setting.

Online library details traits linked to genetic conditions

by  /  31 March 2021

An expanding collection of websites compiles up-to-date information on the characteristics of people with mutations in genes linked to autism and other conditions.

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Top autism-linked gene has divergent effects on brain growth in mice

by  /  25 March 2021

Mutations in CHD8 lead to brain overgrowth or undergrowth in mice, depending on how they affect the gene’s expression.

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Oligodendrocyte shown orange on black in this scanning electron micrograph.

How oligodendrocytes may shape autism

by  /  15 March 2021

A growing body of evidence shows that brain cells called oligodendrocytes may play a larger role in autism than previously thought.

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