A controversial idea about how cells compartmentalize their contents into droplets — like beads of oil in water — could be key to understanding autism, says Julie Forman-Kay.
Spectrum: Autism Research News
Mutations in any of 10 autism-linked genes in frogs lead to the same overabundance of brain cells that develop into neurons; the sex hormone estrogen lowers this excess.
The loss of CHD8, a top autism gene, speeds up the production of certain neurons and leads to overgrowth in spheres of cultured brain cells.
Many people with mutations in the NCKAP1 gene have autism or autism traits, according to a new study spanning seven countries.
People with mutations in CHD8, a top autism gene, tend to be tall and have large heads.
Mice missing a copy of CHD8, a top autism gene, show a signaling imbalance in their brains — a finding in line with a popular hypothesis about autism’s origins.
Children with autism who carry mutations in the chromosomal region 16p11.2 or the gene CHD8 — two of the leading risk factors for autism — show distinct patterns of chemical tags on their DNA.
Children with mutations either in CHD8 — a top autism gene — or in genes that CHD8 controls share similar characteristics.
A team of researchers is trialing a fast approach to autism drug development: simultaneously testing candidates in people and in mice.