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Spectrum: Autism Research News

Tag: CHD8

November 2018
Neurons glow green in mice brain.

Loss of autism gene alters landscape of inhibitory brain signals

by  /  6 November 2018

Mice lacking one copy of a leading autism gene have hyperexcitable brains and problems with learning and memory.

October 2018
A boy toddler learns to walk with an adult holding his hands.

Some ‘autism genes’ show stronger ties to related conditions

by  /  17 October 2018

The largest autism sequencing study to date implicates 99 genes in the condition — but nearly half have a tighter link to intellectual disability or developmental delay.

June 2018

Mice missing top autism gene have overconnected brains

by  /  11 June 2018

Mice with one inactivated copy of CHD8, a top autism gene, show an unusually high degree of synchrony in neural activity between brain regions.


Growth spurt in head, skeleton mark autism in boys

by  /  6 June 2018

Boys with autism have smaller heads, are shorter and weigh less at birth than typical children do — but all that changes by age 3.

March 2018
Mouse in a lab or maze hops around sniffing here and there

Why studying autism in mice may be doomed to fail

by  /  21 March 2018

After more than a decade of effort, scientists are questioning whether mouse models of autism can ever capture the social deficits seen in people with the condition.


How to improve mouse models’ usefulness for understanding autism

by  /  20 March 2018

Integrating human-specific genetic elements into mice may provide a permissive, ‘humanized’ environment for studying autism.

January 2018
three mice with one in the spotlight

‘Retired’ mice find new life as top models for autism

by  /  25 January 2018

As the list of autism candidate genes grows, some mouse models of the genes turn up in long-forgotten studies.

Week of JanuaryJan

Ratio reversal; gender bender; ad accusations and more

by  /  12 January 2018

The male-dominated sex bias in autism is reversed in a related syndrome, a researcher’s gender could influence her study’s outcome, and an award-nominated ad featuring a young man with autism draws criticism.

October 2017
Grid of 8 portraits of children with characteristic facial features

Small head, speech delay characterize mutations in autism gene

by  /  16 October 2017

Children with mutations in a gene called DYRK1A, a leading autism candidate, have a distinct set of features, including intellectual disability, speech delay, motor problems and a small head.

August 2017

Mice made with CRISPR usher in new era of autism research

by  /  7 August 2017

Researchers have debuted two mouse models of autism made using the gene-editing tool CRISPR. Both strains lack one copy of CHD8, a gene with strong ties to autism.