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Spectrum: Autism Research News

Tag: CRISPR

September 2021

New method uses virus-like protein to package, deliver RNA

by  /  9 September 2021

A novel gene delivery system taps a protein found in people to encapsulate messenger RNA and transport it into cells.

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June 2021
Mouse brain cells seen in red

Autism-linked mutation may disrupt brain cell migration

by  /  23 June 2021

Mutations in CUL3, a leading autism gene, may disrupt the movements of neurons during development; correcting this misdirection could lead to an autism therapy.

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CRISPR tool creates long-lasting epigenome alterations

by  /  11 June 2021

A new spin on the classic CRISPR gene-editing tool can alter the genome’s chemical tags and suppress gene expression for months.

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February 2021

Mutations in frogs point to autism genes’ shared role in neurogenesis

by  /  10 February 2021

Mutations in any of 10 autism-linked genes in frogs lead to the same overabundance of brain cells that develop into neurons; the sex hormone estrogen lowers this excess.

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December 2020
Micrograph of nerve cells being targeted by CRISPR enzyme to activate the silenced gene in Angelman syndrome

Hot topics in autism research, 2020

23 December 2020

The Spectrum team highlights five topics that distinguished autism research in 2020: diversity in data, gene therapies, subtyping, social circuitry and the ‘autism gene’ debate.

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White lab mouse sitting in a gloved hand.

Notable papers in autism research, 2020

23 December 2020

Gene therapies and the factors influencing autism traits top Spectrum’s list of the 10 most notable research findings we covered in 2020.

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Mutated cells in mouse embryos--the mutations are seen in pink

Autism genes affect development of neurons and glia

by  /  11 December 2020

Researchers have devised a new way of seeing how gene mutations affect cells during development.

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November 2020
Micrograph of nerve cells being targeted by CRISPR enzyme to activate the silenced gene in Angelman syndrome

Prenatal CRISPR therapy blocks Angelman syndrome traits in mice

by  /  9 November 2020

A gene-editing treatment shows long-lasting effects in a mouse model of Angelman syndrome, a genetic condition related to autism.

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October 2020
Ralf Schmid, the research director in Neurodevelopmental diseases at the Gene Therapy Program Orphan Disease Center, loads replicated mouse dna into wells in the gel before applying electric current to test the viability of the dna.

A quest for Quincy: Gene therapies come of age for some forms of autism

by ,  /  14 October 2020

A gene therapy for Angelman syndrome stands at the forefront of efforts to treat autism-linked conditions that stem from single genes.

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September 2020
Zebrafish embryos with various deformities.

CRISPR technique knocks down gene expression in animal embryos

by  /  2 September 2020

A new method that suppresses gene expression in the embryos of fish and mice may help researchers study autism genes in early development.

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