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Spectrum: Autism Research News

Tag: de novo mutations

May 2012

Chromosome exchanges reveal new autism-related genes

by  /  3 May 2012

Large-scale swapping of genetic material between chromosomes may play an important role in autism, according to a study published 27 April in Cell.

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April 2012

Large sequencing study ties autism genes to fragile X

by  /  26 April 2012

Children with autism carry twice as many new and damaging genetic mutations as typically developing children, according to a new study published in Neuron. The researchers also identified intriguing genetic links between autism and fragile X syndrome.

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Hundreds of genes involved in autism, sequencing studies say

by  /  4 April 2012

The largest set of exome sequencing studies of children with autism and their families to date has identified a handful of genes that may increase risk of the disorder, according to research published in Nature.

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March 2012

Genetics: Maternal and paternal age increase risk of autism

by  /  6 March 2012

The odds of having a child with autism begin to rise at age 35 for both men and women, but that risk does not increase further when both parents are over 35, according to a large study published in the March issue of Annals of Epidemiology.

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February 2012

SHANK2 study bolsters ‘multi-hit’ gene model of autism

by  /  13 February 2012

By screening the genomes of hundreds of people with autism and analyzing the effects of newly identified mutations in cultured neurons, researchers have clarified the disorder’s link to the SHANK2 gene.

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January 2012

Sequencing identifies source of mitochondrial disorders

by  /  30 January 2012

Researchers have identified the genetic root of severe mitochondrial disorders in infants whose cases couldn’t be solved by standard genetic testing, according to research published last week in Science Translational Medicine.

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Effect of paternal age seen in girls with autism

by  /  19 January 2012

Children, especially girls, with autism who have older fathers are more likely than those with younger fathers to be the only child with the disorder in their family, according to a new study published 16 December in Autism.

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Genetics: Large variants linked to intellectual disability

by  /  10 January 2012

Intellectual disability is more likely to be associated with multiple, large or non-inherited duplications and deletions of DNA than is autism, according to a study published 7 November in PLoS Genetics.

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December 2011

Genetics: Family pedigrees suggest autism gene candidates

by  /  14 December 2011

Researchers have identified 12 duplications or deletions of DNA regions that are transmitted along with autism in families with a history of the disorder. The results were published 7 October in PLoS One.

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Genomic liability

by  /  9 December 2011

The rise of whole-genome sequencing is likely to result in a deluge of lawsuits against doctors for misinterpreting disease risks, two lawyers caution in an essay in Slate.

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