Many of the genes strongly linked to autism are involved in the remodeling of chromatin, the complex of DNA and proteins that makes up chromosomes. Scientists are just beginning to understand why.
A new spin on the classic CRISPR gene-editing tool can alter the genome’s chemical tags and suppress gene expression for months.
Some neurons activate autism-linked genes when they fire, according to a new study.
Altering a protein linked to Rett syndrome so that it cannot bind to a methylation tag in neurons results in Rett-like traits in mice.
Mutations in the autism-linked gene DNMT3A lead to the behaviors and gene-expression changes seen in different neurodevelopmental conditions.
A pair of new atlases that profile millions of cells across 15 organs offer an unparalleled look at gene activity during fetal development.
An analysis of four molecular datasets shows a distinct signature, including changes in gene expression and chemical DNA modifications, in some autism brains.
A gene therapy for Angelman syndrome stands at the forefront of efforts to treat autism-linked conditions that stem from single genes.
The most comprehensive catalog to date of DNA regions that modify gene expression is helping researchers uncover the role these segments play in autism.
Older men and women are more likely than young ones to have a child with autism, but this connection is not straightforward.