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Tag: excitatory signaling

March 2021
mouse brain neurons highlighted pink and green.
News / Toolbox

New technique tunes in to molecular chatter in neurons

by  /  11 March 2021

Researchers have devised a way to use fluorescent sensors to detect many different signaling molecules in a cell at once.

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January 2021
neurons in mice
News

Sensory perception, cell signals disrupted in people and mice missing autism gene

by  /  13 January 2021

People and mice with only one working copy of the autism gene SYNGAP1 may have trouble processing sights and sounds.

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lab mice
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Mice with autism-related mutations show brain signaling imbalance

by  /  4 January 2021

Mutations in POGZ, a gene strongly linked to autism, lead to a signaling imbalance in multiple brain regions in mice, according to two new studies.

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November 2020
SYNGAP1 protein between neurons.
News

Reactions from the 2020 SYNGAP1 Scientific Conference

by  /  25 November 2020

Spectrum is covering the 2020 International SYNGAP1 Scientific Conference, which took place virtually because of the coronavirus pandemic. Here we’re highlighting researchers’ reactions to noteworthy presentations.

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October 2020
neurons in green.
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Brain organoids reveal neuronal flaws in syndrome tied to autism

by  /  12 October 2020

Neurons derived from people with 22q11.2 deletion syndrome show deficits in calcium signaling and electrical activity, pointing to possible therapeutic targets.

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September 2020
Brain images showing differences in signaling in autistic and normal brains.
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Brain signal imbalance tracks with sex and with camouflaging autism traits

by  /  17 September 2020

Autistic men show a greater imbalance between excitatory and inhibitory signaling in the brain than autistic women do, which could explain sex differences in ‘camouflaging.’

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Neurons in a macaque cortex express parvalbumin in red.
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Virus-based method manipulates inhibitory neurons in brains

by  /  9 September 2020

A new viral tool can selectively control different types of neurons that dampen brain activity in rodents, monkeys and people.

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Liquid medicine being poured from bottle onto spoon.
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Bumetanide may benefit only a subset of autistic children

by  /  3 September 2020

Contrary to previous results, the blood pressure drug did not uniformly improve autism traits in a new clinical trial.

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August 2020
Micrograph of neurons in mouse brain.
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Inside scientists’ quest to map, modulate social circuits in autism

by  /  17 August 2020

A growing number of studies are revealing circuits that may underlie social challenges in autism — and how to fine-tune them.

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Mouse brain images show proteins in mouse brains at different ages.
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New ‘synaptome’ maps neuronal connections in mouse brain across lifespan

by  /  5 August 2020

A new atlas lays bare how synapses, or the junctions between neurons, change from birth to old age in mice.

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