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Spectrum: Autism Research News

Tag: FMR1

June 2014

Molecular mechanisms: Fragile X gene tied to cocaine effects

by  /  24 June 2014

The protein missing in fragile X syndrome is necessary for mice to respond to the stimulant cocaine, according to a study published 7 May in Neuron.


Molecular mechanisms: DNA loops shut down fragile X gene

by  /  10 June 2014

A repeated sequence within the gene mutated in fragile X syndrome forms unusual loops of genetic material, reports a study published 17 April in PLoS Genetics. The loops may trigger a cascade of genetic changes that push a precursor mutation into one that causes the disorder.


For autism research, rats may be new top model

by  /  9 June 2014

Two new rat models of autism don’t roughhouse like normal rats do, and show some compulsive behaviors, according to a study published in April in Behavioral Neuroscience. The models underscore the advantage rats have over mice in modeling complex social behaviors. 

May 2014

Clinical research: Mothers’ genes give clues to fragile X

by  /  16 May 2014

The symptom severity of three girls with fragile X syndrome tracks with how much the levels of the fragile X protein in their blood differs from that of their unaffected mothers. If the results, published 29 January in Molecular Syndromology, are confirmed in a larger study, they may help doctors predict how the disorder will manifest in girls.

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Misdirected neurons may underlie autism symptoms

by  /  13 May 2014

Proteins that help guide neurons to their correct destination in the brain may be involved in autism, says Christopher Cowan.


Molecular mechanisms: Fragile X protein promotes pruning

by  /  13 May 2014

FMRP, the protein absent or mutated in fragile X syndrome, aids in strategic elimination of neuronal connections during brain development in mice, according to a study published 26 February in The Journal of Neuroscience.


Genetics: Tuberous sclerosis, fragile X share immune changes

by  /  6 May 2014

Two autism-related disorders share disruptions in immune pathways despite major differences in the individual genes affected, according to a study published 24 February in Molecular Autism.

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March 2014

RNA binds to fragile X gene, shutting it down

by  /  13 March 2014

Misplaced pieces of RNA bind and disable the gene responsible for fragile X syndrome, leading to the disorder, according to a study published 28 February in Science.


Genetics: Fragile X mutation leads to syndrome

by  /  11 March 2014

A teenager with fragile X syndrome carries a rare mutation that changes a single amino acid in the FMRP protein, researchers reported 22 January in the European Journal of Human Genetics.


No longer junk: Role of long noncoding RNAs in autism risk

by ,  /  4 March 2014

Long pieces of RNA that do not code for protein have diverse and important roles in the cell and may contribute to autism risk, say Nikolaos Mellios and Mriganka Sur.