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Spectrum: Autism Research News

Tag: FMR1

November 2014

Diabetes drug is sweet cure for fragile X in fruit flies

by  /  19 November 2014

The memory and sleep troubles that accompany fragile X syndrome originate in a glitch in insulin signaling, suggests an unpublished study of fruit flies presented today at the 2014 Society for Neuroscience annual meeting in Washington, D.C. The study points to a widely available diabetes treatment for the syndrome.


Non-starring cells may be key in fragile X syndrome

by  /  17 November 2014

Mice missing the FMR1 gene only in star-shaped brain cells called astrocytes recapitulate key features of fragile X syndrome. Researchers presented the unpublished results today at the 2014 Society for Neuroscience annual meeting in Washington, D.C.

October 2014

Web of genes may hold clues for autism treatments

by  /  20 October 2014

Many of the genes that have emerged as the strongest autism candidates have turned out to regulate the expression of hundreds, if not thousands, of other genes. Within these networks, scientists are homing in on pathways that underlie autism.


Analysis of mouse brains maps subgroups of autism

by  /  13 October 2014

A brain imaging study of 26 mouse models of autism reveals a broad range of structural abnormalities. The models cluster into groups with similar features, reports a study published 9 September in Molecular Psychiatry.

September 2014

New algorithm detects DNA insertions and deletions

by  /  10 September 2014

A new algorithm accurately detects large DNA insertions and deletions in the protein-coding regions of the genome.

June 2014

Molecular mechanisms: Fragile X gene tied to cocaine effects

by  /  24 June 2014

The protein missing in fragile X syndrome is necessary for mice to respond to the stimulant cocaine, according to a study published 7 May in Neuron.


Molecular mechanisms: DNA loops shut down fragile X gene

by  /  10 June 2014

A repeated sequence within the gene mutated in fragile X syndrome forms unusual loops of genetic material, reports a study published 17 April in PLoS Genetics. The loops may trigger a cascade of genetic changes that push a precursor mutation into one that causes the disorder.


For autism research, rats may be new top model

by  /  9 June 2014

Two new rat models of autism don’t roughhouse like normal rats do, and show some compulsive behaviors, according to a study published in April in Behavioral Neuroscience. The models underscore the advantage rats have over mice in modeling complex social behaviors. 

May 2014

Clinical research: Mothers’ genes give clues to fragile X

by  /  16 May 2014

The symptom severity of three girls with fragile X syndrome tracks with how much the levels of the fragile X protein in their blood differs from that of their unaffected mothers. If the results, published 29 January in Molecular Syndromology, are confirmed in a larger study, they may help doctors predict how the disorder will manifest in girls.

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Misdirected neurons may underlie autism symptoms

by  /  13 May 2014

Proteins that help guide neurons to their correct destination in the brain may be involved in autism, says Christopher Cowan.