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Spectrum: Autism Research News

Tag: FMRP

April 2022
Book cover conceptual illustration of chromosome superimposed with genetic tree.

A whisper of autism: Fragile X carriers and the autism phenotype

by  /  21 April 2022

Among people who carry the fragile X premutation, about 14 percent of boys and 5 percent of girls meet the criteria for autism, but the ‘broad autism phenotype’ may be far more common.

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January 2022
Micrograph showing distinct RNA species found in CA1 hippocampal neuronal cell bodies (yellow) and dendrites (red) undergoing compartmentalized RNA regulation.

Location prompts fragile X protein to flip its function

by  /  31 January 2022

The protein, FMRP, shapes cell signaling near synapses but switches to regulate genes in the cell body, according to new research.

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September 2021
Many people in different areas on a target.

Finding a path forward for fragile X drugs

by  /  23 September 2021

The stubborn lack of treatments for fragile X syndrome — a leading cause of inherited intellectual disability and autism — is spurring researchers to revise clinical trial techniques and revisit old drug candidates.

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Steve Warren

Remembering Steve Warren (1953-2021): A giant in the field of genetics

Steve Warren co-discovered the genetic mechanism that underpins fragile X syndrome and was a generous, inspiring mentor to many.

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August 2021

Molecular overlap links tuberous sclerosis, fragile X

by  /  16 August 2021

Brain cells from the cerebellums of mice that model tuberous sclerosis show dampened levels of proteins controlled by FMRP, the protein missing in fragile X syndrome.

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May 2021
Dr. Elizabeth Berry-Kravis stretching during a run.

Elizabeth Berry-Kravis: Running a marathon for fragile X syndrome

by  /  26 May 2021

Elizabeth Berry-Kravis has spent decades uncovering molecular clues to fragile X syndrome and crafting trials of treatments. Her efforts are paying off.

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March 2021
Hands of researcher in two colors, one hand with Fragile X and the other with COIVD shapes connected by multicolored dots.

Fragile X researcher takes on COVID-19

by  /  2 March 2021

Cara Westmark has spent the past year building the case that a drug designed for fragile X syndrome might help coronavirus patients, too.

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December 2020
Micrograph of nerve cells being targeted by CRISPR enzyme to activate the silenced gene in Angelman syndrome

Hot topics in autism research, 2020

by  /  23 December 2020

The Spectrum team highlights five topics that distinguished autism research in 2020: diversity in data, gene therapies, subtyping, social circuitry and the ‘autism gene’ debate.

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October 2020
Adolescent has cheek swabbed

Autism, intellectual disability linked to levels of fragile X protein

by  /  26 October 2020

People with particularly low levels of FMRP, the protein lacking in those with fragile X syndrome, are more likely to also have autism and severe intellectual disability.

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September 2020
Micrograph of a mitochondria.

Fragile X syndrome traits may stem from leaky mitochondria

by  /  11 September 2020

Plugging a leaky mitochondrial membrane may help fragile X neurons to mature and function more efficiently.

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