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Spectrum: Autism Research News


June 2011

Drug trials for fragile X syndrome lead the way for autism

by  /  21 June 2011

Several targeted trials on drugs that treat fragile X syndrome are under way. But accurate endpoints to measure the drugs’ effectiveness are crucial, argues developmental and behavioral pediatrician Randi Hagerman.

May 2011

Scientists probe puzzling overlap of epilepsy and autism

by  /  12 May 2011

Large studies on the epidemiology and genetics of epilepsy and autism have uncovered commonalities between the two disorders. But scientists are only beginning to untangle the biological roots of the overlap.

February 2011

Genetic background alters behavior of fragile X mice

by  /  21 February 2011

Six strains of mice lacking a gene associated with fragile X syndrome show radically different behaviors though they share the same mutation, researchers reported in January in Autism Research.


Molecular mechanisms: Mice model milder form of fragile X

by  /  16 February 2011

A partial mutation that leads to a milder form of fragile X syndrome causes deficits in learning and memory in mice, and alters the connections between their neurons, according to a study published in January in Neurobiology of Disease.


Molecular mechanisms: Men with fragile X have enlarged brains

by  /  9 February 2011

Men with fragile X syndrome have larger brains overall than controls do, but less matter in regions involved in language and social interaction.

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January 2011

New drug rescues function in fragile X syndrome

by  /  20 January 2011

A new drug appears to relieve symptoms of fragile X syndrome by blocking the over-production of a key protein in a subset of people with the disorder, according to a 6 January study in Science Translational Medicine.

December 2010

Molecular mechanisms: New pathway for fragile X treatment

by  /  2 December 2010

Inhibiting the ERK1/2 pathway — which regulates the synthesis of other proteins — can rescue some of the effects of fragile X syndrome, according to a study published 17 November in the Journal of Neuroscience. The ERK pathway could provide a novel target for fragile X therapies.

November 2010

Antibiotic proves promising as fragile X treatment

by  /  19 November 2010

Minocycline, an antibiotic approved to treat various infections including acne, can increase vocalizations and provide long-lasting improvements in anxiety in a fragile X mouse model, according to two posters presented at the Society for Neuroscience annual meeting in San Diego.

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Mouse model hints at Alzheimer’s therapies for fragile X

by  /  19 November 2010

Lowering the levels of proteins associated with Alzheimer’s disease can improve symptoms of fragile X syndrome in mice, according to a poster presented Wednesday at the Society for Neuroscience annual meeting in San Diego.


Fragile X mice have shortage of synaptic proteins

by  /  18 November 2010

The brains of young mice with fragile X syndrome show a dearth of two proteins that are important at the synapse, the junction between neurons, researchers reported Tuesday at the Society for Neuroscience annual meeting in San Diego.