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Spectrum: Autism Research News

Tag: FMRP

November 2017
magnetic stimulation of human brain

Magnetic stimulation bares imbalance of activity in fragile X brains

by  /  14 November 2017

Researchers have used transcranial magnetic stimulation to show that people with fragile X syndrome have weak ‘inhibitory’ signals, those that dampen neuronal activity in the brain.

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white lab rat

‘Fragile’ behaviors mar studies of popular autism mouse model

by  /  13 November 2017

Researchers should proceed with caution when studying the behavior of one of the most popular mouse models of autism: the fragile X mouse model.

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lab mice

Fragile X behaviors may stem from gene’s loss in specific cells

by  /  13 November 2017

Deleting FMR1, the gene mutated in fragile X syndrome, in subsets of mouse neurons leads to distinct features of the condition.

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September 2017
Illustration of Protein factories at neuronal junctions

Protein factories at neuronal junctions take center stage in autism

by ,  /  12 September 2017

Some genes linked to autism regulate the production of proteins at neuronal junctions, suggesting that disrupted protein synthesis contributes to the condition.

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March 2017
illustration of person with autism struggling with addiction

Autism’s hidden habit

by  /  1 March 2017

Conventional wisdom holds that people with autism don’t get hooked on alcohol or other drugs, but new evidence suggests otherwise.

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February 2017
Several arrows have fallen short of their target, which is a pill on a bullseye. This image suggests that a drug targeted towards autism's symptoms has not yet been made.

Why don’t we have better drugs for autism?

by  /  15 February 2017

Clinical trials for autism drugs have been plagued with problems: bad design, the wrong measures, too broad a range of participants. All that is finally starting to change.

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November 2016

Despite setbacks, fragile X drugs file into clinical trials

by  /  30 November 2016

Our infographic displays efforts to develop treatments for fragile X syndrome. So far, none of them have passed muster in clinical trials.

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September 2016

Glowing cells bolster search for fragile X drugs

by  /  2 September 2016

A new genetic trick allows researchers to quickly spot the most promising treatments for fragile X syndrome among thousands of candidate compounds.

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July 2016

Gene-editing tool locates proteins inside brain cells

by  /  8 July 2016

The popular gene-editing tool CRISPR can tag proteins in the brain, illuminating the whereabouts of autism candidates.

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May 2016

Experimental cancer drug restores memory in fragile X mice

by  /  26 May 2016

An early-stage treatment for eye cancer reverses memory problems in a mouse model of fragile X syndrome.

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