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Spectrum: Autism Research News

Tag: FMRP

March 2016

Webinar: Claudia Bagni details molecular pathways in fragile X syndrome

23 March 2016

Watch the replay of Claudia Bagni’s webinar, in which she described molecular pathways that are impaired in fragile X syndrome, autism and schizophrenia. She also discussed mouse and fly models, as well as human cells.

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October 2015

Genetic fix for star-shaped cells eases fragile X in mice

by  /  20 October 2015

Boosting levels of the fragile X protein FMRP in astrocytes reverses features of fragile X syndrome in mice.

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New methods tighten ​net​ around autism genes

by  /  9 October 2015

Autism researchers are sharpening their statistical tools to make sense of the growing pool of autism genes.

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June 2015

Enzyme’s discovery points to new approach for fragile X

by  /  16 June 2015

Researchers have discovered an enzyme that lowers brain levels of FMRP, the protein missing in people with fragile X syndrome. Blocking the enzyme may ease fragile X symptoms in people with the disorder who have low levels of FMRP and mild symptoms.

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May 2015

Questions for Miller, Kaplan: New neurons’ role in autism

by  /  12 May 2015

An autism-linked gene controls the number of neurons in the developing brain. Freda Miller and David Kaplan say the finding points to a new role for the gene in the early embryo.

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March 2015

Questions for Eric Klann: Translating treatments for fragile X

by  /  30 March 2015

Treatments for fragile X syndrome may be more successful if they block direct targets of the key missing protein, says Eric Klann.

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Treatment eases fragile X symptoms in flies, mice

by  /  9 March 2015

Blocking an enzyme involved in learning and memory corrects brain abnormalities and improves memory in fly and mouse models of fragile X syndrome.

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January 2015

Drug abates symptoms in two genetic models of autism

by  /  19 January 2015

Drugs developed to treat fragile X syndrome may also work for autism because both disorders feature defects at neuronal junctions, suggests a paper published 12 January in Nature Neuroscience.

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October 2014

Web of genes may hold clues for autism treatments

by  /  20 October 2014

Many of the genes that have emerged as the strongest autism candidates have turned out to regulate the expression of hundreds, if not thousands, of other genes. Within these networks, scientists are homing in on pathways that underlie autism.

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September 2014

New algorithm detects DNA insertions and deletions

by  /  10 September 2014

A new algorithm accurately detects large DNA insertions and deletions in the protein-coding regions of the genome.

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