The popular gene-editing tool CRISPR can tag proteins in the brain, illuminating the whereabouts of autism candidates.
Spectrum: Autism Research News
An early-stage treatment for eye cancer reverses memory problems in a mouse model of fragile X syndrome.
Watch the replay of Claudia Bagni’s webinar, in which she described molecular pathways that are impaired in fragile X syndrome, autism and schizophrenia. She also discussed mouse and fly models, as well as human cells.
Boosting levels of the fragile X protein FMRP in astrocytes reverses features of fragile X syndrome in mice.
Researchers have discovered an enzyme that lowers brain levels of FMRP, the protein missing in people with fragile X syndrome. Blocking the enzyme may ease fragile X symptoms in people with the disorder who have low levels of FMRP and mild symptoms.
An autism-linked gene controls the number of neurons in the developing brain. Freda Miller and David Kaplan say the finding points to a new role for the gene in the early embryo.
Treatments for fragile X syndrome may be more successful if they block direct targets of the key missing protein, says Eric Klann.
Drugs developed to treat fragile X syndrome may also work for autism because both disorders feature defects at neuronal junctions, suggests a paper published 12 January in Nature Neuroscience.