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Spectrum: Autism Research News

Tag: FMRP

March 2013

Alzheimer’s drugs hold promise for autism

by  /  11 March 2013

A growing number of studies suggest connections between Alzheimer’s disease, fragile X syndrome and autism, which could point the way to potential treatments.

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February 2013

Molecular mechanisms: Study links excess protein to autism

by  /  20 February 2013

Elevated levels of EIF4E, which plays a key role in protein synthesis, lead to autism-like behaviors and abnormal neuronal signaling in mice, according to a study published 17 January in Nature.

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Molecular mechanisms: Pruning path links autism, fragile X

by  /  1 February 2013

The protein lacking in fragile X syndrome works with three autism-linked proteins to fine-tune the connections between neurons, according to a study published 21 December in Cell.

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January 2013

Hunt for targets of fragile X protein proves perplexing

by  /  31 January 2013

FMRP, the protein missing in fragile X syndrome, binds to the RNA sequences of 939 genes, 93 of which have been linked to autism, according to a study published 20 December in Nature.

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December 2012

Clinical research: Larger brains in autism, fragile X

by  /  19 December 2012

Young boys with fragile X syndrome or autism have larger brains overall than controls do, but the two groups show enlargement of different parts of the brain, according to an imaging study published in September in the Journal of the American Academy of Child and Adolescent Psychiatry.

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October 2012

Fragile X syndrome can be treated in adulthood

by  /  19 October 2012

Activating the expression of FMR1, the gene mutated in fragile X syndrome, in adult mice reverses symptoms of the syndrome, according to a poster presented Monday at the Society for Neuroscience annual meeting in New Orleans.

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Statin pills in a blisterpack on a couch.

Cholesterol drug may treat fragile X syndrome

by  /  17 October 2012

A cholesterol-lowering drug called lovastatin prevents seizures in mice that model fragile X syndrome, according to a poster presented Sunday at the 2012 Society for Neuroscience annual meeting in New Orleans.

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Researchers uncover new drug target for fragile X

by  /  4 October 2012

Deleting an enzyme that regulates protein synthesis reverses some of the molecular and behavioral deficits in a mouse model of fragile X syndrome, according to research published 2 October in Neuron.

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September 2012

Drug improves social deficits in fragile X syndrome

by  /  19 September 2012

A drug called arbaclofen improves behavioral problems in people with fragile X syndrome, an inherited condition that can lead to mental retardation and autism, according to the results of a clinical trial published today in Science Translational Medicine. A second study published in the same journal showed that the drug restores normal brain function in a mouse model of the disorder.

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August 2012

Molecular mechanisms: Serotonin mimics may treat fragile X

by  /  28 August 2012

Compounds that target the receptor for the chemical messenger serotonin could help treat fragile X syndrome, according to a study published 17 July in Biological Psychiatry.  

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