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Spectrum: Autism Research News

Tag: FMRP

March 2013

Fragile X mutation may lead to noisy brain signals

by  /  28 March 2013

Researchers have uncovered a new role for the protein missing in fragile X syndrome — it regulates the release of neurotransmitters, chemical messengers in the brain, according to a mouse study published 20 February in Neuron.

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Rho family of enzymes at crossroads of autism

by  /  12 March 2013

A number of autism risk factors converge on one cellular pathway: abnormal remodeling of the cell’s structural systems through the signaling protein Rho, says SFARI’s associate director for research, Alan Packer.

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Alzheimer’s drugs hold promise for autism

by  /  11 March 2013

A growing number of studies suggest connections between Alzheimer’s disease, fragile X syndrome and autism, which could point the way to potential treatments.

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February 2013

Molecular mechanisms: Study links excess protein to autism

by  /  20 February 2013

Elevated levels of EIF4E, which plays a key role in protein synthesis, lead to autism-like behaviors and abnormal neuronal signaling in mice, according to a study published 17 January in Nature.

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Molecular mechanisms: Pruning path links autism, fragile X

by  /  1 February 2013

The protein lacking in fragile X syndrome works with three autism-linked proteins to fine-tune the connections between neurons, according to a study published 21 December in Cell.

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January 2013

Hunt for targets of fragile X protein proves perplexing

by  /  31 January 2013

FMRP, the protein missing in fragile X syndrome, binds to the RNA sequences of 939 genes, 93 of which have been linked to autism, according to a study published 20 December in Nature.

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December 2012

Clinical research: Larger brains in autism, fragile X

by  /  19 December 2012

Young boys with fragile X syndrome or autism have larger brains overall than controls do, but the two groups show enlargement of different parts of the brain, according to an imaging study published in September in the Journal of the American Academy of Child and Adolescent Psychiatry.

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October 2012

Fragile X syndrome can be treated in adulthood

by  /  19 October 2012

Activating the expression of FMR1, the gene mutated in fragile X syndrome, in adult mice reverses symptoms of the syndrome, according to a poster presented Monday at the Society for Neuroscience annual meeting in New Orleans.

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Statin pills in a blisterpack on a couch.

Cholesterol drug may treat fragile X syndrome

by  /  17 October 2012

A cholesterol-lowering drug called lovastatin prevents seizures in mice that model fragile X syndrome, according to a poster presented Sunday at the 2012 Society for Neuroscience annual meeting in New Orleans.

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Researchers uncover new drug target for fragile X

by  /  4 October 2012

Deleting an enzyme that regulates protein synthesis reverses some of the molecular and behavioral deficits in a mouse model of fragile X syndrome, according to research published 2 October in Neuron.

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