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Spectrum: Autism Research News

Tag: FMRP

November 2011

Molecular mechanisms: Neurons excitable in fragile X mice

by  /  22 November 2011

Neurons from mice that model fragile X syndrome may fire signals more readily than neurons from controls, according to a study published 5 October in The Journal of Neuroscience. The results suggest a cause for the high incidence of seizures in individuals with the syndrome.

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Mouse study points to potential therapy for fragile X syndrome

by  /  15 November 2011

A protein involved in the cascade of interactions at the junctions between neurons points to a potential therapy for fragile X syndrome, according to unpublished data presented at the 2011 Society for Neuroscience annual meeting in Washington, D.C.

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Video: What is the fragile X protein’s role in a neuron?

by  /  15 November 2011

The fragile X protein FMRP helps make proteins at the synapse, the junction between neurons, even when the genetic instructions for doing so are located far away in the nucleus, says Kimberly Huber.

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Molecular mechanisms: Fragile X drugs could treat autism

by  /  1 November 2011

Postmortem brains from adults with autism have lower-than-normal levels of the fragile X mental retardation protein, which is missing in individuals with fragile X syndrome.

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September 2011

The big sleep

by  /  2 September 2011

A new review suggests that sleep problems in neurodevelopmental disorders don’t just reflect underlying weaknesses in neural circuitry; they actively intensify these deficits.

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Cognition and behavior: Fragile X treatment has ill effects

by  /  2 September 2011

A compound that shows promise as a treatment for fragile X syndrome alleviates repetitive behaviors in mice, but unexpectedly makes them less social.

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July 2011

Fragile X protein found to regulate key autism candidates

by  /  28 July 2011

The protein missing in people with fragile X syndrome regulates the activity of more than 800 other proteins, including some key players in autism, according to a study published 22 July in Cell. Many of these autism-associated proteins cluster on either side of the synapse, the junction between neurons.

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Molecular mechanisms: Fragments of RNA regulate synapse

by  /  27 July 2011

Small fragments of RNA, called microRNAs, can fine-tune the levels of proteins at the junctions between neurons in response to cell signals, according to a study published 10 June in Molecular Cell.

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Mouse study raises questions about fragile X treatment

by  /  18 July 2011

Blocking a chemical messenger — a much-touted approach to treating fragile X syndrome — is unlikely to completely reverse symptoms of the disorder, according to a provocative new study. The results, published in May in Behavioural Brain Research, show only modest behavioral improvements with the approach.

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Clinical research: Infertile women should be tested for fragile X

by  /  6 July 2011

Women with a mild version of primary ovarian insufficiency, a disorder that mimics the symptoms of menopause, should be tested for a mutation that can lead to fragile X syndrome, according to a study published 15 June in Human Reproduction.

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