An expanding collection of websites compiles up-to-date information on the characteristics of people with mutations in genes linked to autism and other conditions.
Spectrum: Autism Research News
Mutations in TBR1, a candidate gene for autism, compromise its functions and its ability to bind its partners — including FOXP2. Alan Packer explores the gene’s emerging link to language.
To understand the role of FOXP2, a gene that links autism and language, researchers should look at its partner genes and at language models such as songbirds, say Genevieve Konopka and Todd Roberts.
FOXP2, a language gene that is linked to autism, may regulate active connections between neurons by controlling the levels of a protein called SRPX2, according to a study published 22 November in Science.
Researchers have created a network of various forms of many proteins linked to autism, revealing new molecular interactions that may play a role in the disorder. The unpublished work was presented in a poster last week at the Salk Institute, Fondation IPSEN and Nature Symposium on Biological Complexity in La Jolla, California.
FOXP2, a protein linked to language development that regulates the expression of some autism-associated genes, also dampens expression of DISC1, mutations in which have been linked to both schizophrenia and autism. The results were published 20 March in Human Molecular Genetics.
Mice with mutations in a gene tied to language impairment and to autism have trouble learning to associate sounds with motor patterns, says a study published last week in PLoS ONE.
Regions of the genome that contain the same genetic variants on both copies of a chromosome are more likely to contain autism-associated genes than other parts of the genome, according to a study published 14 October in Human Genetics.