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Spectrum: Autism Research News

Tag: gene expression

June 2021

Brain activity patterns may distinguish girls with autism

by  /  2 June 2021

Atypical patterns of neuronal activity and gene expression in the striatum may characterize autism in girls, according to a new study.

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May 2021
Illustration of a researcher trying to navigate sea of genomic data.

Family approach yields new autism-linked genes

by  /  21 May 2021

About one-third of the HNRNP gene family’s 33 members may be associated with neurodevelopmental conditions, including autism.

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Mouse gut cells in blue, purple and pink

Loss of top autism-linked gene from gut alters behavior in mice

by  /  4 May 2021

Deleting CHD8 from the intestines induces gastrointestinal and behavioral changes in mice that resemble traits in people with mutations in the gene.

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April 2021
Colorful RNA in mouse brain slice

Tissue-swelling method divulges RNA locations, sequences in cells

by  /  28 April 2021

A technique that expands tissue before spotting and sequencing RNA — the molecular messenger for DNA — enables researchers to see where particular genes are expressed in cells.

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Mouse brains carrying CUL3 gene mutation reveal unusually thin cortical tissue.

Neuron ‘skeleton’ may explain impact of autism-linked gene mutation

by  /  16 April 2021

Mutations in CUL3, a gene strongly linked to autism, may cause differences in brain structure by disrupting cytoskeleton proteins, according to a new study.

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A group of six images of fruit fly brains show networks in green and pink.

Poor sleep could be core feature of autism, related conditions

by  /  15 April 2021

Fruit flies with low expression of a gene linked to neurodevelopment have disrupted sleep, poor memory and altered social behavior.

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March 2021

Innate stress response may link maternal infection to autism

by  /  19 March 2021

A typically protective stress response could help to explain the connection between maternal illness and neurodevelopmental conditions.

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Tiny cortical organoids in petri dish

Year-old organoids echo genetic shifts seen at birth

by  /  8 March 2021

3D cultures of human brain cells kept alive for more than a year undergo transitions in gene activity that resemble those seen in newborns, and may be used to study autism genes in postnatal stages of brain development.

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A digital rendering of a green neuron on black

Brain activity jump-starts autism-linked genes in human neurons

by  /  5 March 2021

Some neurons activate autism-linked genes when they fire, according to a new study.

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Broken protein bridge linked to Rett syndrome traits

by  /  1 March 2021

Altering a protein linked to Rett syndrome so that it cannot bind to a methylation tag in neurons results in Rett-like traits in mice.

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