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Spectrum: Autism Research News

Tag: gene expression

October 2020
Gut neurons and glia (red, green) are fragile and interwoven with other cells (blue) in the colon, making them tricky to isolate.

Cell maps reveal diversity of neurons in gut

by  /  21 October 2020

An atlas that details gene expression in neurons and other cells from the intestines of mice and people may help to elucidate the link between gut problems and autism.

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Mother and child having a conversation in nature.

Traits in mothers may signal gene variants for autism

by  /  16 October 2020

Autistic children’s traits track with subtle, autism-like behaviors in their mothers; women with these traits may also carry a genetic predisposition to the condition.

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Ralf Schmid, the research director in Neurodevelopmental diseases at the Gene Therapy Program Orphan Disease Center, loads replicated mouse dna into wells in the gel before applying electric current to test the viability of the dna.

A quest for Quincy: Gene therapies come of age for some forms of autism

by ,  /  14 October 2020

A gene therapy for Angelman syndrome stands at the forefront of efforts to treat autism-linked conditions that stem from single genes.

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Brain hemispheres color-coded.

Autism shares brain structure changes with other psychiatric conditions

by  /  1 October 2020

Atypical development of a particular type of neuron explains the structural similarities seen in the brains of people with autism, schizophrenia and other conditions, according to a new study.

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September 2020
Neurons in a macaque cortex express parvalbumin in red.

Virus-based method manipulates inhibitory neurons in brains

by  /  9 September 2020

A new viral tool can selectively control different types of neurons that dampen brain activity in rodents, monkeys and people.

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Zebrafish embryos with various deformities.

CRISPR technique knocks down gene expression in animal embryos

by  /  2 September 2020

A new method that suppresses gene expression in the embryos of fish and mice may help researchers study autism genes in early development.

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August 2020
Proteins binding to RNA, illustration.

Massive encyclopedia catalogs genome’s regulatory regions

by  /  26 August 2020

The most comprehensive catalog to date of DNA regions that modify gene expression is helping researchers uncover the role these segments play in autism.

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Fat in bloodstream visualized as yellow balls, floating near blood cells, macro view.

Blood lipid levels may be altered in some autistic people

by  /  10 August 2020

About 6.5 percent of autistic people in the United States also have dyslipidemia, a condition characterized by abnormal lipids levels in the blood.

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July 2020
micrograph of a slice of mouse brain

Autism genes may play key role in development of amygdala

by  /  27 July 2020

Nearly all genes with moderate to strong ties to autism are expressed in the developing amygdala; a few show altered expression in the amygdalae of autistic people.

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Micrograph of muscle cells

Some motor problems in autism may arise from cells outside brain

by  /  20 July 2020

The autism gene SHANK3 is crucial for the development and function of muscles and the motor neurons that control them.

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