Researchers have uncovered 38 genes, including 9 autism candidates, that may fine-tune brain activity.
Spectrum: Autism Research News
Tag: gene networks
A new computer program predicts the effects of mutations in regions of the genome that control gene expression. Researchers can use the tool, called DeepBind, to gauge whether autism-linked mutations might block the genetic landing strips for regulatory proteins.
DNA sequences called enhancers — which boost the expression of genes from within or outside them — are enriched for genetic variants linked to autism, suggests a new study. The finding may help researchers understand how variants outside genes contribute to autism.
A new strategy sharpens the analysis of chemical tags on the DNA-protein complexes that regulate gene expression. The method may help researchers decipher how gene expression goes awry in disorders such as autism.
People with autism are twice as likely to carry alterations in genes that regulate the circadian clock, or the body’s sleep-wake cycle as those without the disorder. The findings may help explain why most children with autism have trouble with sleep.
Researchers have for the first time mapped gene expression in the rhesus macaque brain from birth through adulthood. The atlas illuminates the expression patterns of genes likely to be important in autism.