Researchers have engineered two new rats with mutations in a family of genes that function at neuronal junctions, they reported today at the 2014 International Meeting for Autism Research in Atlanta.
Spectrum: Autism Research News
Mice with either too little or too much MeCP2, the gene mutated in Rett syndrome, show similar malfunctions in a learning and memory circuit.
The brain’s memory center, the hippocampus, may provide clues to features of autism as disparate as personal relationships and decision-making.
Researchers have charted gene expression in the brains of rhesus macaques from before birth into adulthood.
Mice with a mutation in CHD8, the top autism gene, show no signs of any of the condition’s core features.
A drug that curbs the expression of MeCP2, a gene duplicated in people with an autism-linked syndrome, normalizes brain function and reverses abnormal behaviors in mice.
Rare antibodies taken from the blood of women who have a child with autism cause brain structure changes and autism-like symptoms in male mice.