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Spectrum: Autism Research News

Tag: imprinting

March 2017

Parental origin may alter gene copies’ expression in brain

by  /  13 March 2017

Some neurons preferentially express the copy of a gene inherited from one parent over the other.

October 2016

Parental age has different impact on autism, schizophrenia

by  /  31 October 2016

Children born to parents who are 35 or older are at an increased risk of autism; for schizophrenia, the increased risk is limited to those born to mothers in their teens or early 20s.

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October 2015

Glowing cells reveal how DNA tags shift over time

by  /  7 October 2015

A new method lets researchers spy on cells as they gain and lose chemical tags on their DNA.

May 2015

Parents’ DNA tags tied to autism symptoms in toddlers

by  /  14 May 2015

Women who have unusual patterns of chemical tags on their DNA during pregnancy may give birth to children who develop autism symptoms. The preliminary results are being presented today at the 2015 International Meeting for Autism Research in Salt Lake City, Utah.

January 2015

Tweak to molecular scissors cuts path to turn on genes

by  /  26 January 2015

A new technique allows scientists to turn on the expression of any gene, giving them the unprecedented ability to explore the function of every gene in the human genome.

March 2014

No longer junk: Role of long noncoding RNAs in autism risk

by ,  /  4 March 2014

Long pieces of RNA that do not code for protein have diverse and important roles in the cell and may contribute to autism risk, say Nikolaos Mellios and Mriganka Sur.

October 2013

Gene screen reveals altered chemical tags in autism brains

by  /  14 October 2013

One of the largest genome-wide screens of methyl tags in postmortem brains has found that people with autism have three unique regions of methylation — chemical modifications that affect gene expression. The results were reported 3 September in Molecular Psychiatry.

September 2013

Molecular mechanisms: Study shows Angelman drug’s actions

by  /  24 September 2013

Researchers have uncovered the mechanism by which a candidate drug for Angelman syndrome activates UBE3A, the gene that is silenced in the syndrome, according to a study published 20 August in the Proceedings of the National Academy of Sciences.


Gene expression in neurons may not match number of copies

by  /  23 September 2013

Neurons derived from individuals who carry extra copies of an autism-linked chromosomal region have gene expression patterns that are unexpectedly similar to those of neurons with deletions of the region. The unpublished findings were presented Thursday at the Dup15q Alliance Scientific Meeting in Sacramento, California.


What does the existence of long genes tell us?

by  /  23 September 2013

Long genes, and their relationship to a class of enzymes that regulate gene expression, raise intriguing questions about the risk for neuropsychiatric disorders.