Worms and zebrafish missing both copies of the gene CHD7 have disrupted cellular signaling, a dearth of inhibitory neurons and behavior changes — all of which are reversed by the stimulant drug ephedrine.
Spectrum: Autism Research News
Female mice missing a copy of the autism-linked gene MECP2 in a specific set of inhibitory neurons have a hard time heeding pups’ calls and herding litters.
Sensory problems in people with fragile X syndrome may stem from hyperactive neurons, a mouse model study suggests.
Mice missing an autism gene called SHANK3 tend to be hypersensitive to touch, which may stem from underactivity of neurons that normally dampen sensory responses.
Deleting an autism gene called TRIO derails neurons’ journey to their destination.
Injecting cells called interneurons into the brains of a mouse model of autism restores typical social behavior. But the reason for this effect is a puzzle.
The signaling imbalance theory holds that the brains of autistic people are hyper-excitable because of either excess neuronal activity or weak brakes on that activity.
Lattice-like structures that surround neurons may be overly abundant — or scarce — in brain regions of three autism mouse models.
Mice lacking one copy of a leading autism gene have hyperexcitable brains and problems with learning and memory.