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Spectrum: Autism Research News

Tag: microglia

November 2014

In mouse model of Rett, immune cells overly sensitive

by  /  20 November 2014

Loss of MeCP2, the Rett syndrome gene, depletes immune cells throughout the bodies of mice, researchers reported yesterday at the 2014 Society for Neuroscience annual meeting in Washington, D.C.

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The next hot topic in autism research? Immune cells

by  /  16 November 2014

Some cases of autism may result from glitches in immune cells in the blood: This provocative idea stems from a series of unpublished mouse studies presented yesterday at the 2014 Society for Neuroscience annual meeting in Washington, D.C.

March 2014

Molecular mechanisms: Star-shaped cells abound in autism

by  /  18 March 2014

Brains from people with autism have more support cells called glia and fewer neurons than do control brains, suggests a study published 10 January in Molecular Autism.

February 2014

Gene expression implicates inhibitory neurons in autism

by  /  26 February 2014

By matching the genes expressed in particular cell types with those linked to a disorder, researchers may be able to identify the cell types implicated in the disorder, they report in a study published 22 January in the Journal of Neuroscience. They use this method to link interneurons and immune cells to autism.


Scarcity of brain’s immune cells alters mouse behavior

by  /  13 February 2014

A temporary shortage of microglia — immune cells in the brain that prune unnecessary neural connections — in infancy can have long-lasting effects on brain circuits and behavior, according to a study published in Nature Neuroscience on 2 February.

November 2013

Study spells caution for bone marrow transplants for Rett

by  /  12 November 2013

Bone marrow transplants, which have been shown to arrest symptoms of Rett syndrome in young mice, have little effect on older mice, according to preliminary results presented Monday at the 2013 Society for Neuroscience annual meeting in San Diego. The findings suggest that this approach may not be a viable treatment for those who already have symptoms of the disorder.


Brain’s immune cells boost rapid transmission of signals

by  /  11 November 2013

Two new studies bolster the emerging idea that microglia, cells that were long dismissed as passive soldiers of the brain’s immune system, are in fact actively involved in shoring up connections between neurons. The unpublished work was presented Sunday at the 2013 Society for Neuroscience annual meeting in San Diego.

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Beth Stevens discusses brain immunity and wiring

20 November 2013

Watch the complete replay of Beth Stevens discussing the link between immune cells in the brain, neuronal junctions and autism. Submit follow-up questions.

September 2013

Duplication of chromosome 15 region mirrors autism

by  /  23 September 2013

People with autism and those with duplications of the 15q11-13 chromosomal region share a distinctive pattern of gene expression in the brain, according to unpublished research presented Friday at the Dup15q Alliance Scientific Meeting in Sacramento, California.

August 2013

Abnormal brain immune cells: Autism’s cause or result?

by  /  19 August 2013

Mounting evidence finds abnormally high levels of immune cells in the brains of people with autism. But how do we separate cause from effect?