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Spectrum: Autism Research News

Tag: microglia

January 2013

Molecular mechanisms: Immune soldiers elevated in autism

by  /  4 January 2013

Children with autism have higher levels than controls of dendritic cells, a subset of immune cells, according to a study published 11 October in Brain Behavior and Immunity.

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December 2012

Molecular mechanisms: Star cells abnormal in autism brains

by  /  7 December 2012

Postmortem brains from individuals with autism have astrocytes that are smaller but denser than in control brains, according to a study published 21 September in the Journal of Neuroinflammation. The researchers found similar alterations in a mouse that lacks the autism-linked gene NLGN3.

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October 2012

‘Spiny mice’ model risk of autism from maternal infection

by  /  10 October 2012

The so-called ‘spiny mouse’ species has a gestational period twice as long as that of typical laboratory mice. This makes them good models for studying the link between prenatal exposure and autism risk, according to a study published 29 August in Brain, Behavior and Immunity.

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August 2012

Bone marrow transplant curbs autism symptoms in mice

by  /  16 August 2012

An altered immune system can cause autism-like behaviors, suggests a study published 31 July in the Proceedings of the National Academy of Sciences. The researchers found that a bone marrow transplant, which restores the animals’ immune system, alleviates their anxiety and repetitive behavior.

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June 2012

Molecular mechanisms: Microglia abnormal in autism brains

by  /  5 June 2012

Two new postmortem studies show that microglia, which protect the brain from invaders, are denser and more concentrated around neurons in the brains of individuals with autism than in those of controls.

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Immune cells sculpt brain by pruning neuronal connections

by  /  4 June 2012

Immune cells called microglia may play a central role in trimming synapses, the connections between neurons, according to research published 24 May in Neuron. These modifications are part of a normal developmental process by which excess synapses in the brain are destroyed.

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May 2012

New technique helps locate source of brain imaging signals

by  /  16 May 2012

Combining functional magnetic resonance imaging of rat brains with a technique that uses light to detect neuronal activity can help researchers hone in on the source of the activity, according to a study published 6 May in Nature Methods.

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March 2012

Bone marrow transplant alleviates Rett symptoms in mice

by  /  19 March 2012

A bone marrow transplant from healthy mice to those lacking the MeCP2 protein, which causes Rett syndrome, extends lifespan and alleviates symptoms of the disorder, according to research published online 18 March in Nature.

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January 2012

The value of blood cells in autism research

by  /  10 January 2012

Blood from individuals with autism could help researchers identify biomarkers to diagnose the disorder and learn more about related symptoms, such as gastrointestinal complaints, says molecular biologist Valerie Hu.

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May 2011

Networks of genes altered in autism brains, study says

by  /  25 May 2011

Two networks of genes are abnormally expressed in the brains of people with autism, according to a study published today in Nature.

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