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Spectrum: Autism Research News

Tag: mouse models

March 2021

Top autism-linked gene has divergent effects on brain growth in mice

by  /  25 March 2021

Mutations in CHD8 lead to brain overgrowth or undergrowth in mice, depending on how they affect the gene’s expression.

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Mouse brain neurons labeled with a genetic marker show pink on a dramatic blue background.

Early training forestalls motor, memory difficulties in mouse model of Rett syndrome

by  /  24 March 2021

Motor and memory training early in life postpones the onset of difficulties in those areas in a mouse model of Rett syndrome, and stimulating neurons involved in those skills appears to mimic the effects of training.

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Innate stress response may link maternal infection to autism

by  /  19 March 2021

A typically protective stress response could help to explain the connection between maternal illness and neurodevelopmental conditions.

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Collage illustration: Modern white lab mice look across an abyss to a cohort of historical illustrations of animals.

New statistical method may spare lab animals

by  /  18 March 2021

An online tool could help researchers limit the number of animals needed to power their studies.

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Oligodendrocyte shown orange on black in this scanning electron micrograph.

How oligodendrocytes may shape autism

by  /  15 March 2021

A growing body of evidence shows that brain cells called oligodendrocytes may play a larger role in autism than previously thought.

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Hands of researcher in two colors, one hand with Fragile X and the other with COIVD shapes connected by multicolored dots.

Fragile X researcher takes on COVID-19

by  /  2 March 2021

Cara Westmark has spent the past year building the case that a drug designed for fragile X syndrome might help coronavirus patients, too.

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Broken protein bridge linked to Rett syndrome traits

by  /  1 March 2021

Altering a protein linked to Rett syndrome so that it cannot bind to a methylation tag in neurons results in Rett-like traits in mice.

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February 2021
Oligodendrocyte gene grouping showing network of blue lines connecting the gene names on reddish bubbles.

Differing gene functions across species may pose problems for autism models

by  /  22 February 2021

Misaligned gene expression maps suggest that some autism-linked genes play distinct roles in mouse and human brains.

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Transmission Electron micrograph shows mitochondria colored an aqua blue.

Changes to mitochondrial DNA spur autism-like traits in mice

by  /  17 February 2021

Mice with a mutation in their mitochondrial DNA show altered brain activity, repetitive behaviors and reduced sociability, according to a new study.

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cells in a mouse brain show the mutations in green.

Molecular switch marks mosaic mutations in mice

by  /  11 February 2021

A new tool enables researchers to create mosaic mutations in only some cells and then accurately identify which cells are affected.

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