Mutations in CHD8 lead to brain overgrowth or undergrowth in mice, depending on how they affect the gene’s expression.
Spectrum: Autism Research News
Tag: mouse models
Motor and memory training early in life postpones the onset of difficulties in those areas in a mouse model of Rett syndrome, and stimulating neurons involved in those skills appears to mimic the effects of training.
A typically protective stress response could help to explain the connection between maternal illness and neurodevelopmental conditions.
Altering a protein linked to Rett syndrome so that it cannot bind to a methylation tag in neurons results in Rett-like traits in mice.
Misaligned gene expression maps suggest that some autism-linked genes play distinct roles in mouse and human brains.
Mice with a mutation in their mitochondrial DNA show altered brain activity, repetitive behaviors and reduced sociability, according to a new study.