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Spectrum: Autism Research News

Tag: mouse models

February 2021
Serotonin proteins

Sensor helps scientists spy on serotonin activity in mice in real time

by  /  5 February 2021

A glowing protein tracks serotonin levels and location in the brains of living mice and could yield clues to the neurotransmitter’s role in autism.

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January 2021
3D image of a rat with motion sensor nodes on, in a clear cage.

Motion-capture videos reveal atypical grooming in fragile X rats

by  /  27 January 2021

A Hollywood-inspired video tool that captures movement in three dimensions over extended time periods shows that rats lacking the autism-linked gene FMR1 have different grooming patterns than controls do.

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Portrait of André Fenton.

Webinar: André Fenton on rethinking dysfunction in fragile X model mice

10 February 2021

On 10 February, André Fenton spoke about rethinking dysfunction in fragile X model mice.

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Mouse brain slices shown in red

Vasopressin relieves social deficits in an autism mouse model

by  /  25 January 2021

Mice missing a copy of MAGEL2 have trouble discerning between a familiar mouse and an unfamiliar one; treating them with the social hormone vasopressin reverses this deficit.

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DNMT3A protein attaches a methyl group tag onto the DNA base cytosine.

Autism-related conditions converge on same loss of DNA tags

by  /  20 January 2021

Mutations in the autism-linked gene DNMT3A lead to the behaviors and gene-expression changes seen in different neurodevelopmental conditions.

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Lost sleep sparks lasting social problems in SHANK3 mice

by  /  14 January 2021

Sleep disruption early in life has long-lasting consequences for mice missing a copy of the autism-linked gene SHANK3.

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Mouse with her pup

Malfunctioning neurons mute sound processing in mouse model of Rett syndrome

by  /  14 January 2021

Female mice missing a copy of the autism-linked gene MECP2 in a specific set of inhibitory neurons have a hard time heeding pups’ calls and herding litters.

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Mouse on gray background looks at something out of frame.

Inability to attend to cues may cause sensory challenges in fragile X mice

by  /  14 January 2021

Sensory problems in people with fragile X syndrome may stem from hyperactive neurons, a mouse model study suggests.

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neurons in mice

Sensory perception, cell signals disrupted in people and mice missing autism gene

by  /  13 January 2021

People and mice with only one working copy of the autism gene SYNGAP1 may have trouble processing sights and sounds.

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Mouse brain scan video still in black and white.

New mouse brain atlas traces connections in fine detail

by  /  13 January 2021

A new wiring diagram of the mouse brain could help autism researchers better study how brain connections vary in mice with different genetic backgrounds.

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