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Spectrum: Autism Research News

Tag: mouse models

January 2021
Two mice in a rotarod machine

Mouse study sounds note of caution for Rett syndrome therapies

by  /  13 January 2021

Treatments for Rett syndrome that aim to boost levels of the protein MECP2 may not help everyone with the condition.

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Four white mice on a rotarod, blue background.

Motor skills, brain volume affected in mouse model of DDX3X syndrome

by  /  13 January 2021

Mice missing one copy of the autism-linked gene DDX3X have smaller brains and worse motor skills than mice with both copies of the gene, according to a new unpublished study.

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Neurons in cerebella of mice with fewer branches and spines.

Cerebellum alterations crop up in mice missing autism gene

by  /  12 January 2021

Deleting the autism-linked gene CNTNAP2 from mice leads to distinct cellular and electrical changes in the cerebellum, according to two unpublished studies presented virtually today at the 2021 Society for Neuroscience Global Connectome.

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dopamine neurons in mice show up green in an area of the brain associated with social reward.

Dopamine neurons may dampen social behavior in mouse model of autism

by  /  12 January 2021

Mice missing a copy of the autism-linked gene PTEN show a reduced preference for social interaction, possibly due to atypically large, overconnected dopamine neurons. Easing the overconnection may alleviate this trait.

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Proteins present at neuronal junctions.

Repeat labeling helps reveal synaptic proteins

by  /  12 January 2021

A novel microscopy technique offers the most detailed look to date at the proteins present at neuronal junctions.

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Neurons show structural changes, seen in black and white.

Loss of a top autism gene may alter neuron structure

by  /  12 January 2021

Mutations in the autism-linked gene ASH1L change how neurons grow and develop.

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Lab mice in cage

‘Litter effects’ may skew findings in mouse studies

by  /  11 January 2021

Even when they share identical genetic backgrounds, mice from separate litters show different patterns of development, according to a new study.

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Heat map of mouse activity.

Circuit linking prefrontal cortex and brain’s relay station regulates social behavior in mice

by  /  11 January 2021

A set of neurons connecting the prefrontal cortex and the thalamus helps regulate social interactions in mice.

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lab mice

Mice with autism-related mutations show brain signaling imbalance

by  /  4 January 2021

Mutations in POGZ, a gene strongly linked to autism, lead to a signaling imbalance in multiple brain regions in mice, according to two new studies.

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December 2020
White lab mouse sitting in a gloved hand.

Notable papers in autism research, 2020

23 December 2020

Gene therapies and the factors influencing autism traits top Spectrum’s list of the 10 most notable research findings we covered in 2020.

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