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Tag: postmortem brains

February 2021
Oligodendrocyte gene grouping showing network of blue lines connecting the gene names on reddish bubbles.

Differing gene functions across species may pose problems for autism models

by  /  22 February 2021

Misaligned gene expression maps suggest that some autism-linked genes play distinct roles in mouse and human brains.

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December 2020
Brain images color-coded to show structural changes in autism.

Gene expression maps reveal origins of brain changes from autism mutations

by  /  4 December 2020

A new study pinpoints the genes and cell types that may underlie the atypical brain structure seen in people with genetic conditions linked to autism.

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October 2020

Integrating molecular data may reveal subgroups of autism

by  /  30 October 2020

An analysis of four molecular datasets shows a distinct signature, including changes in gene expression and chemical DNA modifications, in some autism brains.

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Brain hemispheres color-coded.

Autism shares brain structure changes with other psychiatric conditions

by  /  1 October 2020

Atypical development of a particular type of neuron explains the structural similarities seen in the brains of people with autism, schizophrenia and other conditions, according to a new study.

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July 2020
micrograph of a slice of mouse brain

Autism genes may play key role in development of amygdala

by  /  27 July 2020

Nearly all genes with moderate to strong ties to autism are expressed in the developing amygdala; a few show altered expression in the amygdalae of autistic people.

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An illustration of the brain shows the amydala highlighted in green among botanical forms that look like neurons.

Amygdala, the brain’s threat detector, has broad roles in autism

by  /  14 July 2020

The amygdala has long been a focus of autism research. But its exact role in the condition has been unclear.

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May 2020
Human brain with prefrontal cortex highlighted.

DNA differences may shape gene expression in the brain before birth

by  /  7 May 2020

Many genes in a brain region implicated in autism change expression patterns in late fetal development, depending on differences in neighboring DNA.

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February 2020
Toddler is balancing with help from mom

Little-known gene tied to autism, developmental delay

by  /  28 February 2020

Rare mutations in a gene called BAZ2B are associated with various conditions of brain development, including autism.

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December 2019

Notable papers in autism research in 2019

23 December 2019

This year’s top papers deepen our understanding of autism’s genetics and reveal mixed results from trials of autism therapies.

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November 2019
micrographs of blood vessels in the brain

Surplus of immune cells may mark brains of autistic people

by  /  11 November 2019

Blood vessels in the brains of more than half of autistic people have an unusually large number of T cells.

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