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Spectrum: Autism Research News

Tag: PTEN

November 2014

Genetics first: A fresh take on autism’s diversity

by  /  24 November 2014

Each child with autism is different from the next. One approach rapidly gaining momentum makes sense of this diversity by grouping children together based on their genetics, then looking for patterns in their symptoms. The long-term aim: personalized treatments for each subtype of autism.

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Diabetes drug is sweet cure for fragile X in fruit flies

by  /  19 November 2014

The memory and sleep troubles that accompany fragile X syndrome originate in a glitch in insulin signaling, suggests an unpublished study of fruit flies presented today at the 2014 Society for Neuroscience annual meeting in Washington, D.C. The study points to a widely available diabetes treatment for the syndrome.

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Autism-linked gene guides growth of subtype of neurons

by  /  19 November 2014

Mice missing PTEN, a strong autism candidate gene, in a subtype of inhibitory neurons in one part of the brain show signaling abnormalities and social deficits. Researchers presented the unpublished work yesterday at the 2014 Society for Neuroscience annual meeting in Washington, D.C.

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October 2014

Scientists catalog effects of PTEN mutations in autism

by  /  27 October 2014

People with autism who have mutations in a gene called PTEN have a distinct profile of cognitive impairments and structural abnormalities in the brain. The profile, published 7 October in Molecular Psychiatry, points to a subtype of autism with these features.

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Seizures trigger autism-like behaviors in mice

by  /  23 October 2014

Mice with an extra copy of the autism-linked gene UBE3A show abnormal social behavior after experiencing recurrent seizures. The findings, presented Tuesday at the Autism Consortium Research Symposium in Boston, provide one possible explanation for why seizures and autism often go hand in hand.

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April 2014

High-throughput screen finds genes that link neurons

by  /  30 April 2014

A new algorithm allows researchers to search among hundreds of genes and identify those involved in building synapses, the junctions that transmit signals between neurons, according to a report published 14 March in PLoS One.

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Molecular mechanisms: Mutant mice seek out social contact

by  /  29 April 2014

Male mice that carry a specific mutation in the autism-linked PTEN gene have enlarged brains and show heightened interest in other mice, according to a study published 7 February in Human Molecular Genetics.

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March 2014

Molecular mechanisms: Mild fragile X seen in partial mutants

by  /  4 March 2014

Removing the fragile X syndrome gene from two brain regions in mice leads to signaling defects but does not produce behavioral deficits, according to a study published in the February issue of Autism Research.

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December 2013

Understanding contradictory connectivity reports in autism

by ,  /  10 December 2013

Studies at the level of neural circuits are needed to better understand the importance of both increased and decreased connectivity between different regions in the autism brain, say John Rubenstein and Vikaas Sohal.

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November 2013

Molecular mechanisms: Autism mutation dulls neurons

by  /  19 November 2013

Loss of one copy of the autism-linked gene PTEN in mouse neurons boosts production of a certain ion channel, and decreases the neurons’ firing rate, according to a study published 21 October in Proceedings of the National Academy of Sciences.

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