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Spectrum: Autism Research News

Tag: PTEN

March 2013

Genetics: Head size heterogeneous in autism

by  /  6 March 2013

Children who have autism and large heads may belong to different clinical subsets based on the ratio between their head size and height, according to a study published in the February issue of Autism Research.

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February 2013

Molecular mechanisms: Study links excess protein to autism

by  /  20 February 2013

Elevated levels of EIF4E, which plays a key role in protein synthesis, lead to autism-like behaviors and abnormal neuronal signaling in mice, according to a study published 17 January in Nature.

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Twin study suggests large head size runs in autism families

by  /  14 February 2013

Children with autism and their unaffected twins have heads that are significantly larger than average, according to a study published 16 January in the Journal of Autism and Developmental Disorders.

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January 2013

Hunt for targets of fragile X protein proves perplexing

by  /  31 January 2013

FMRP, the protein missing in fragile X syndrome, binds to the RNA sequences of 939 genes, 93 of which have been linked to autism, according to a study published 20 December in Nature.

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December 2012

Study supports flawed protein synthesis theory of autism

by  /  17 December 2012

A new study bolsters the idea that overactive protein synthesis contributes to autism. The findings, published 21 November in Nature, show that dampening a single overabundant protein, neuroligin-1, reverses both abnormal brain activity and social deficits in mice.

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October 2012

Mouse model links autism risk gene to mitochondria

by  /  11 October 2012

A new mouse model provides the first molecular link between the known autism risk gene PTEN and the mitochondrial dysfunction sometimes seen in the disorder. Mice with half the normal amount of PTEN protein in their brains have social deficits reminiscent of autism and faulty mitochondria, according to a study published 10 August in PLoS One.

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May 2012

Autism gene PTEN plays vital role in neural stem cells

by  /  31 May 2012

Knocking out an autism-linked gene called PTEN only in neural stem cells of the hippocampus, a brain region central to learning and memory, throws the development of new neurons off course in adult mice, according to research published last month in the Journal of Neuroscience.

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April 2012

Molecular mechanisms: Autism gene modulates connectivity

by  /  10 April 2012

Neurons lacking PTEN, an autism-associated gene also involved in cancer, are hyperconnected to both near and distant brain cells, according to a study published 1 February in The Journal of Neuroscience.

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December 2011

Molecular mechanisms: Master regulator altered in autism

by  /  16 December 2011

SP1, a protein that regulates the expression of several autism candidate genes, could increase risk of the disorder by simultaneously altering the expression of a number of the genes, according to a study published 24 October in Biological Psychiatry.

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November 2011

Molecular mechanisms: Fragile X drugs could treat autism

by  /  1 November 2011

Postmortem brains from adults with autism have lower-than-normal levels of the fragile X mental retardation protein, which is missing in individuals with fragile X syndrome.

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