The animals recall fear more readily if a set of inhibitory neurons in the hippocampus is switched on.
Spectrum: Autism Research News
Tag: Rett syndrome
The new animal line could accelerate the discovery of gene-activating therapies for the autism-linked condition Rett syndrome.
Mutations in a newly identified protein complex that interacts with the Rett protein also lead to a Rett-like condition in mice, researchers say.
The Rett Syndrome Global Registry is gathering data from people around the world with the rare condition to support clinical trials.
A basic scientist at heart, Hollis Cline has spent decades pushing the boundaries of what researchers can see in the brain. Her persistence has led to a deeper understanding of how some autism-linked genes influence brain development.
Clues that problems with mitochondria contribute to autism have been accumulating for decades. In the past five years, a mutant mouse and a flurry of findings have energized the field.
A MECP2 gene therapy for Rett syndrome eases repetitive behaviors, anxiety and hyperactivity in a mouse model of Pitt-Hopkins syndrome.
These short reports from Spectrum journalists highlight some of the autism-related findings that caught our attention at the meeting this past week.
Jolting a bundle of nerve fibers deep in the brain restores learning and memory in mice with mutations of the autism-linked gene CDKL5.
As treatments for some autism-linked genetic conditions inch closer to the clinic, researchers are talking more urgently about screening all newborns for such conditions.