There is some evidence that neural habituation — the process by which neurons get used to sensory stimuli — goes awry in autism. Mutant fish may help us understand the sensory sensitivities that often accompany the disorder, says Alan Packer.
Spectrum: Autism Research News
Tag: Rett syndrome
A new study may help explain why the symptoms of Rett syndrome appear 6 to 18 months after birth. It suggests that the role of MeCP2, the protein missing in the syndrome, becomes more important as the brain matures.
Researchers from four labs were unable to reproduce the findings from a high-profile 2012 study in which bone marrow transplants dramatically extended the lives of mice with features of Rett syndrome. Their sobering findings were published yesterday in Nature.
Mutations in MeCP2, which cause Rett syndrome, boost the expression of long genes in the brain. The findings add to mounting evidence linking long genes to developmental disorders.
Getting to a diagnosis of autism or another neurodevelopmental disorder is a long and frustrating experience for some families — especially when it comes to finding the underlying genetic cause. DNA sequencing could ease this arduous journey.
Scientists have created a transgenic monkey modeling Rett syndrome, they announced yesterday at the 2014 Society for Neuroscience annual meeting in Washington, D.C. This model and others sparked a lively discussion about the relative value of animal models in research.
Loss of MeCP2, the Rett syndrome gene, depletes immune cells throughout the bodies of mice, researchers reported yesterday at the 2014 Society for Neuroscience annual meeting in Washington, D.C.
Neurons derived from the skin cells of boys with Rett syndrome can help screen potential treatments for the disorder, suggest unpublished results presented yesterday at the 2014 Society for Neuroscience annual meeting in Washington, D.C.