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Spectrum: Autism Research News

Tag: Rett syndrome

June 2015

Startled fish help sound out sensory overload in autism

by  /  8 June 2015

There is some evidence that neural habituation — the process by which neurons get used to sensory stimuli — goes awry in autism. Mutant fish may help us understand the sensory sensitivities that often accompany the disorder, says Alan Packer.

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May 2015

Buildup of gene tags may clarify timing of Rett syndrome

by  /  22 May 2015

A new study may help explain why the symptoms of Rett syndrome appear 6 to 18 months after birth. It suggests that the role of MeCP2, the protein missing in the syndrome, becomes more important as the brain matures.

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Study questions promise of bone marrow transplant for Rett

by  /  22 May 2015

Researchers from four labs were unable to reproduce the findings from a high-profile 2012 study in which bone marrow transplants dramatically extended the lives of mice with features of Rett syndrome. Their sobering findings were published yesterday in Nature.

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April 2015

Rett mutation may lead to runaway inflammation

by  /  30 April 2015

The mutation that causes Rett syndrome may spark uncontrolled inflammation throughout the body and brain, suggests a study published last week. The findings may explain the syndrome’s wide range of symptoms, from seizures to gut problems.

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New data implicate unusually long genes in Rett syndrome

by  /  13 April 2015

Mutations in MeCP2, which cause Rett syndrome, boost the expression of long genes in the brain. The findings add to mounting evidence linking long genes to developmental disorders.

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February 2015

Autism gene guides early neuron development

by  /  12 February 2015

The little-studied autism gene ANKRD11 helps to package DNA in the nucleus and plays a critical role in the early growth and positioning of neurons.

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December 2014

Sequencing may offer smoother sailing in diagnostic odyssey

by  /  16 December 2014

Getting to a diagnosis of autism or another neurodevelopmental disorder is a long and frustrating experience for some families — especially when it comes to finding the underlying genetic cause. DNA sequencing could ease this arduous journey.

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November 2014

Monkey missing Rett gene prompts primate research debate

by  /  20 November 2014

Scientists have created a transgenic monkey modeling Rett syndrome, they announced yesterday at the 2014 Society for Neuroscience annual meeting in Washington, D.C. This model and others sparked a lively discussion about the relative value of animal models in research.

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In mouse model of Rett, immune cells overly sensitive

by  /  20 November 2014

Loss of MeCP2, the Rett syndrome gene, depletes immune cells throughout the bodies of mice, researchers reported yesterday at the 2014 Society for Neuroscience annual meeting in Washington, D.C.

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Growth factor rescues neurons made from boys with Rett

by  /  18 November 2014

Neurons derived from the skin cells of boys with Rett syndrome can help screen potential treatments for the disorder, suggest unpublished results presented yesterday at the 2014 Society for Neuroscience annual meeting in Washington, D.C.

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