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Spectrum: Autism Research News

Tag: Rett syndrome

April 2010

Random genetic changes may explain variability in autism

by  /  13 April 2010

Random changes in gene expression can cause genetically identical embryos to develop different traits, according to a study of worms published in Nature. The findings suggest that haphazard movements of molecules could partly explain why autism-associated mutations don’t always cause the same symptoms.

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Rett gene found to control genome structure in neurons

by  /  9 April 2010

The protein that is mutated in Rett syndrome controls the expression of other genes by changing the way DNA packs into a cell, rather than turning genes on or off, according to a study published in Molecular Cell.

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March 2010

Autism and fragile X feature immune signatures

by  /  30 March 2010

Scientists have identified distinct blood signatures of cytokines — proteins that control communication between cells of the immune system — in individuals with fragile X syndrome and autism.

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December 2009

Pupil response to light could be biomarker for autism

by  /  11 December 2009

The pupils of children with autism contract more slowly in response to flashes of light than those of their healthy peers, according to findings published in the November issue of the Journal of Autism and Developmental Disorders.

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Autism shares features with cerebellar syndromes

by  /  3 December 2009

There are clinical, anatomical and genetic overlaps between autism and certain rare developmental disorders of the cerebellum, and these disorders may help scientists understand autism, according to several studies published in the past year.

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November 2009

MeCP2 loss leads to smaller neurons in brain region

by  /  18 November 2009

Deleting MeCP2, the gene that’s mutated in Rett syndrome, alters both the size and function of neurons in the mouse brain — at least in one brain region, the locus ceruleus — according to a 30 September report in the Journal of Neuroscience.

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Autism marked by altered trajectory of brain growth

by  /  3 November 2009

Although the head overall is bigger in some children with autism, researchers have found more informative differences in size — some smaller, some larger — across regions of the brain.

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October 2009

Enriched environment improves symptoms of Rett

by  /  23 October 2009

Giving mouse models of Rett syndrome access to toys, wheels and contact with other mice rescues motor skill and other deficits characteristic of the disorder, according to results presented in a poster session Wednesday at the Society for Neuroscience meeting in Chicago.

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MeCP2 loss ups inhibitory signaling

by  /  21 October 2009

Selectively disrupting an autism-related gene in cultured human neurons causes a dramatic imbalance of excitation and inhibition in cell signaling, according to unpublished results presented today at the Society for Neuroscience meeting in Chicago.

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June 2009

Study links autism to stem cell development

by  /  23 June 2009

The molecular defects that cause some cases of autism may arise during the development of neuronal stem cells, according to a new theory bolstered by several independent animal and human studies.

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