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Tag: sequencing

September 2021
Four brains showing areas affected by the X chomosome in yellow
News

X chromosome exerts extra influence on brain development

by  /  15 September 2021

The X chromosome holds stronger-than-expected genetic sway over the structure of several brain regions. The genes that may underlie this oversized influence have ties to autism.

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July 2021
Colorful, playful illustrated scene of ewborns on a conveyor belt moving past researchers holding a long, long list.
News

The push to screen newborns for rare autism-linked genetic conditions

by  /  28 July 2021

As treatments for some autism-linked genetic conditions inch closer to the clinic, researchers are talking more urgently about screening all newborns for such conditions.

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News

Ultra-rare variants point to new autism candidate genes

by  /  26 July 2021

A large, whole-genome sequencing study of families yields insights into ultra-rare genetic variants that contribute to autism.

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May 2021
DNA helix inside the human body
News

Autism genetics, explained

by  /  28 May 2021

The more scientists dig into DNA, the more intricate its contribution to autism seems to be. Here, we unravel the complex genetics of autism.

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Computer screenshot showing bands of colour resulting from sequenced DNA.
News

Largest autism genetics analysis to date uncovers more high-confidence candidates

by  /  6 May 2021

The largest-yet study of genetic data from autistic people has identified 255 genes associated with the condition.

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April 2021
Colorful RNA in mouse brain slice
News / Toolbox

Tissue-swelling method divulges RNA locations, sequences in cells

by  /  28 April 2021

A technique that expands tissue before spotting and sequencing RNA — the molecular messenger for DNA — enables researchers to see where particular genes are expressed in cells.

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single celled zygote seen as a colorful cluster of dots, next to a four cell embryo, visualized in the same way.
News / Toolbox

Intact-cell sequencing lays bare new view of genome structure

by  /  22 April 2021

The technique enables researchers to sequence the DNA of an intact cell, providing a unique view of the genome’s organization inside the nucleus.

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March 2021
Brain made of DNA strands on a background of molecule shapes
Opinion / Viewpoint

There are no autism-specific genes, just brain genes

by ,  /  23 March 2021

There is not yet a single example of a gene that, when mutated, increases the likelihood of autism but not of other neurodevelopmental conditions, including intellectual disability.

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A lone Rhesus macaque looks into the camera
News / Toolbox

New macaque reference genome fills sequence gaps

by  /  4 March 2021

Researchers have created the most complete macaque reference genome to date and used it to catalog genetic variation among hundreds of monkeys.

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December 2020
Micrograph of nerve cells being targeted by CRISPR enzyme to activate the silenced gene in Angelman syndrome
Features / Special Reports / Hindsight is 2020: The year in review

Hot topics in autism research, 2020

23 December 2020

The Spectrum team highlights five topics that distinguished autism research in 2020: diversity in data, gene therapies, subtyping, social circuitry and the ‘autism gene’ debate.

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