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Spectrum: Autism Research News

Tag: SHANK3

January 2021
In cortical-striatal assembloids, striatal neurons (magenta) derived from individuals with Phelan-McDermid syndrome fire more frequently than neurons from controls.

Brain ‘assembloids’ capture circuit flaws in syndrome tied to autism

by  /  21 January 2021

Merging 3D clusters of neurons that mimic different brain regions models the atypical electrical activity seen in an autism-related condition.

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Lost sleep sparks lasting social problems in SHANK3 mice

by  /  14 January 2021

Sleep disruption early in life has long-lasting consequences for mice missing a copy of the autism-linked gene SHANK3.

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November 2020
Young zebrafish have transparent skin, which allows researchers to track the movements of glowing beads of excrement through their gut.

Zebrafish and ‘Smurf cakes’ link autism gene mutation to digestive woes

by  /  24 November 2020

Mutations in a top autism gene called SYNGAP1 slow the rate at which zebrafish digest food and pass waste, and may also disrupt gut function in people.

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July 2020
Man working from home office.

INSAR 2020, from home

by  /  31 July 2020

Like so many other events this year, autism’s biggest annual conference — the International Society for Autism Research meeting — was forced to go virtual because of the coronavirus pandemic.

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Micrograph of muscle cells

Some motor problems in autism may arise from cells outside brain

by  /  20 July 2020

The autism gene SHANK3 is crucial for the development and function of muscles and the motor neurons that control them.

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May 2020

Reversing SHANK3 mutations in mice mitigates autism-like traits

by  /  28 May 2020

Correcting an autism gene mutation in fetal mice lessens some autism-like behaviors after birth.

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April 2020
Two neuron images compared side by side

Lithium may treat behavior linked to autism gene

by  /  24 April 2020

The mood-stabilizing drug lithium seems to ease repetitive behaviors seen in mice missing SHANK3, an autism gene.

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March 2020
Close-up of mouse face and whiskers.

Sensory sensitivity in autistic people may stem from subset of neurons

by  /  27 March 2020

Mice missing an autism gene called SHANK3 tend to be hypersensitive to touch, which may stem from underactivity of neurons that normally dampen sensory responses.

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microscopic views of proteins

Alzheimer’s protein turns up as potential target for autism treatments

by  /  2 March 2020

Lowering the levels of a protein called tau, best known for its involvement in Alzheimer’s disease, improves behavior in two mouse models of autism.

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February 2020
brain form in the shape of white flowers on black background with the striatum in red

Striatum, the brain’s reward hub, may drive core autism traits

by  /  17 February 2020

Associated primarily with its role in movement, the striatum may also influence the social difficulties of autistic people.

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