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Spectrum: Autism Research News

Tag: signaling imbalance

October 2021
Closeup photo of a liquid being poured out of a brown bottle.

French pharma firms terminate trials of bumetanide for autism

by  /  1 October 2021

Preliminary results suggested the treatment is no better than placebo at reducing the severity of core autism traits.

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August 2021
Illustration of brain showing overexcited and underexcited parts of the brain represented by jagged and loose squiggles.

Disruptions to brain’s ‘thermostat’ may underpin autism traits

by  /  18 August 2021

Mounting evidence suggests that autism often involves upsets in homeostatic plasticity, a set of processes neurons use to stabilize their activity. These disruptions result from a range of autism-linked mutations and may help to explain the condition’s famed heterogeneity.

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July 2021
Immature inhibitory cells surround mature neuron.

Critical time window flagged for autism gene’s influence

by  /  16 July 2021

A transplant of inhibitory neurons during the second week of life prevents social difficulties and a brain signaling imbalance in mice missing a copy of FOXG1.

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June 2021
Mouse neuron recordings showing different levels of activity before and after an encounter with an unfamiliar mouse.

Neural network captures noisy neurons in autism mouse model

by  /  18 June 2021

Mice missing the autism-linked gene SHANK3 use more neurons to engage in social behavior than control mice do, reflecting a more disorganized, less efficient brain signaling network.

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Brain and marijuana leaves

Q&A with Eric Hollander: Cannabis treatments for autism

by  /  8 June 2021

As cannabis prohibition slowly lifts in the United States, scientists and families in the autism community are increasingly turning to the drug and its constituent compounds to ease autism-related difficulties, including seizures and irritability.

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May 2021

Stimulant restores cell signaling, eases behavior issues in animals missing autism gene

by  /  28 May 2021

Worms and zebrafish missing both copies of the gene CHD7 have disrupted cellular signaling, a dearth of inhibitory neurons and behavior changes — all of which are reversed by the stimulant drug ephedrine.

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Visual stimulus of 4 circles with black and white stripes.

Visual task flags autistic people who respond to GABA agonists

by  /  14 May 2021

The investigational drug arbaclofen makes autistic people’s brains respond to a visual task more like non-autistic people’s brains do.

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Neurons in red and green

‘Neurons on a chip’ reveal patterns across autism-linked conditions

by  /  7 May 2021

Activity patterns of neuronal networks link different genetic subtypes of autism that have similar traits, according to new unpublished research.

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brainstem of rats in red, green and blue highlight higher levels of GABA.

GABA agonist rescues auditory hypersensitivity in rats missing autism-linked gene CNTNAP2

by  /  3 May 2021

The investigational drug arbaclofen may right an imbalance between inhibitory and excitatory signaling in the animals’ brains.

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April 2021
Person itching back of neck.

Sensory issues linked to heart-rate differences in autistic youth

by  /  5 April 2021

Autistic children with sensory issues show more intense physiological reactions to unpleasant sounds and other sensations than their non-autistic peers do, a new study shows.

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