Long pieces of RNA that do not code for protein have diverse and important roles in the cell and may contribute to autism risk, say Nikolaos Mellios and Mriganka Sur.
Spectrum: Autism Research News
Tag: synaptic plasticity
Spontaneous and rare mutations, particularly in genes related to networks that regulate neuronal connections, contribute a small but significant proportion of the risk for schizophrenia, report two large studies published online 22 January in Nature.
Emerging evidence indicates that microglia, the brain’s immune cells, are altered in some individuals with autism, raising questions about their role in brain development, says Beth Stevens.
Newborn mice with an autism-linked mutation in neuroligin-3, which stabilizes junctions between neurons, have abnormal brain chemistry, according to a study published 4 June in Frontiers in Cellular Neuroscience.
Researchers can use light to activate certain proteins that receive signals at the junctions between neurons and that are key targets for fragile X syndrome therapies, according to a study published in the April issue of Nature Neuroscience.
Researchers have added two new candidates to the arsenal of compounds that alleviate both the behavioral and molecular hallmarks of fragile X syndrome in mice that model the disorder. A third candidate, minocycline, improves some symptoms in children with the disorder.