Different mutations in the autism-linked SHANK3 gene lead to distinct glitches at the synapse, the junction between neurons, according to unpublished research presented Tuesday at the 2012 Society for Neuroscience annual meeting in New Orleans.
Spectrum: Autism Research News
Some song-related areas in the zebra finch brain and language areas in the human brain show strikingly similar patterns of gene expression, according to unpublished research presented Sunday at the Society for Neuroscience annual meeting in New Orleans.
One research team is cataloging the vocalizations of 1,000 different mice, and a second group is creating a tool that will allow researchers to distinguish calls made by several mice as they interact, according to two posters presented Sunday at the 2012 Society for Neuroscience annual meeting in New Orleans.
Mice lacking one copy of the autism-linked 16p11.2 chromosomal region are thin, deaf and show repetitive behaviors. They also have altered proportions of neurons in their brains, particularly those that express the chemical messenger dopamine. The unpublished results were presented Sunday at the 2012 Society for Neuroscience annual meeting in New Orleans.
Mice lacking EN2, an autism-linked gene, have a range of behavioral problems, including social deficits, problems with learning and memory, and motor abnormalities, according to a study published 19 July in PLoS One.
Concerned by researchers’ lack of access to a valuable mouse model of autism, a nonprofit advocacy group is dedicating a chunk of its limited resources to the creation of a freely available version.
Losing one or both copies of TSC1, one of the two genes responsible for tuberous sclerosis complex, in specific cells of the cerebellum can trigger several autism-like behaviors in mice, according to research published 1 July in Nature.
Offspring born to pregnant rats with an activated immune system emit more distress calls when they receive electrical shocks than do controls, according to a study published 9 June in the Journal of Psychiatric Research.