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Spectrum: Autism Research News

Tag: whole-exome sequencing

November 2013

Studies map gene expression across brain development

by  /  21 November 2013

Now that genetic studies have implicated several hundred genes in autism, researchers are turning their attention to where and when in the healthy young brain these genes are expressed. The first two studies to tackle these questions appear today in Cell.

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Genetic analysis links autism to missing brain structure

by  /  11 November 2013

The largest genetic analysis yet conducted of people lacking a brain structure called the corpus callosum shows that the condition shares many risk factors with autism. The study was published 3 October in PLoS Genetics. 

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Keeping score

by  /  5 November 2013

An effort to rank autism genes on the strength of the evidence implicating them in the disorder will provide researchers with a focused list of genes to study, says Alan Packer.
 
 

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October 2013

Small deletions, duplications of DNA may up autism risk

by  /  17 October 2013

Two new studies have found more small deletions and duplications of DNA in individuals with autism than in unaffected controls. These variants may also affect the severity of the disorder.

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Gene screen reveals altered chemical tags in autism brains

by  /  14 October 2013

One of the largest genome-wide screens of methyl tags in postmortem brains has found that people with autism have three unique regions of methylation — chemical modifications that affect gene expression. The results were reported 3 September in Molecular Psychiatry.

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September 2013

New model merges data streams to boost gene discovery

by  /  23 September 2013

A new statistical model pulls together information about inherited and spontaneous mutations in a single analysis to enhance the search for autism candidate genes. The method, called transmission and de novo association, or TADA, was described 15 August in PLoS Genetics.

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August 2013

Whole-genome sequencing unearths new autism mutations

by  /  1 August 2013

The first sizable study to use whole-genome sequencing to investigate autism has shown its mettle, revealing new mutations and candidate genes for the disorder, according to a report published 11 July in the American Journal of Human Genetics.

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July 2013

Clinics unroll genome tests for undiagnosed disorders

by  /  8 July 2013

Two university-based clinics have debuted large programs that rely on sequencing to diagnose genetic disorders, including developmental disorders such as autism.

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June 2013

Rare, common variants together boost gene analysis

by  /  5 June 2013

A new statistical method for linking genes to a disorder analyzes both rare and common variants of a gene at the same time, according to a study published 14 May in the American Journal of Human Genetics. This makes it possible to confirm associations that other techniques might overlook.

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May 2013

Simon Fisher: Hunting on the FOXP2 trail

by  /  20 May 2013

Simon Fisher made headlines in 2001 for finding the first gene related to language. He has been following FOXP2 ever since, and has found that it is important in autism and other psychiatric disorders.

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