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Spectrum: Autism Research News

Tag: X chromosome

June 2021
Dr. Huda Zoghbi portrait

Huda Zoghbi: Taking genetic inquiry to the next level

by  /  25 June 2021

Over the course of a career spanning more than three decades, Huda Zoghbi has won almost every major biology and neuroscience research award that exists. More than 20 years since she discovered the gene behind Rett syndrome, she remains laser focused on unlocking the condition’s secrets and finding effective treatments.

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lab technician pipetting in dramatic light

Alternative gene-therapy approaches take aim at Rett syndrome

by  /  16 June 2021

Methods that selectively increase levels of the Rett protein make for safer and more effective treatment strategies, some researchers say.

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December 2020
Brain images color-coded to show structural changes in autism.

Gene expression maps reveal origins of brain changes from autism mutations

by  /  4 December 2020

A new study pinpoints the genes and cell types that may underlie the atypical brain structure seen in people with genetic conditions linked to autism.

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October 2020
Ralf Schmid, the research director in Neurodevelopmental diseases at the Gene Therapy Program Orphan Disease Center, loads replicated mouse dna into wells in the gel before applying electric current to test the viability of the dna.

A quest for Quincy: Gene therapies come of age for some forms of autism

by ,  /  14 October 2020

A gene therapy for Angelman syndrome stands at the forefront of efforts to treat autism-linked conditions that stem from single genes.

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January 2019

Method unravels Rett mutation’s effects on specific brain cells

by  /  11 January 2019

A new technique may reveal how mutations on the X chromosome alter various types of cells in the brain.

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September 2018

New mouse model paves way for Rett syndrome treatments

by  /  7 September 2018

A new line of female mice may enable researchers to test gene-based therapies for Rett syndrome.

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March 2018
Deleting DNA repeats from fragile X neurons restores expression (right, red) of the gene silenced in the syndrome.

CRISPR tweak fixes genetic flaw in fragile X syndrome

by  /  29 March 2018

A modified version of the genetic engineering tool CRISPR may restore expression of the gene mutated in fragile X syndrome.

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October 2017
Brain scans of boys with fragile X syndrome fall into distinct groupings.

Brain scans reveal subtypes of fragile X syndrome in boys

by  /  30 October 2017

Differences in brain structure may distinguish boys with relatively mild features of fragile X syndrome from those with a severe form of the condition.

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Microscope image of neuronal injections in brain.

Two drugs ease features of autism syndromes in mice

by  /  11 October 2017

Drugs that block certain brain enzymes could help treat two conditions associated with autism.

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Week of OctoberOct
2nd
2017

Cannabis candidate; omega add-on; oxytocin control and more

by  /  6 October 2017

A cannabis gel may ease features of fragile X syndrome, omega fatty acids show promise for autism in two trials, and oxytocin reinforces social behaviors through the brain’s reward pathway.

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