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Spectrum: Autism Research News

TOPIC

Genes

Rare or common, inherited or spontaneous, mutations form the core of autism risk.

October 2010

Nature vs. nurture

by  /  29 October 2010

Mice with social behavior deficits reminiscent of autism are friendlier when raised alongside a highly social mouse strain.

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Linkage study reveals parent-of-origin effects in autism

by  /  29 October 2010

The first genome-wide linkage analysis of more than 1,200 families has identified regions implicated in autism as originating from either the paternal or maternal copies of chromosomes.

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Storing structure

by  /  28 October 2010

The National Institutes of Health on 30 September launched a public database to catalog a particularly important type of genomic data: so-called ‘structural variations’ — large deletions, duplications and rearrangements of DNA.

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New technique maps mutation-rich regions

by  /  28 October 2010

Researchers have mapped unique identifiers in the regions around human genes that are at risk for duplication or deletion, allowing precise sequencing of nearly 1,000 genes for the first time, according to a paper published today in Science.

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Database groups common concepts in autism tests

by  /  27 October 2010

A searchable new database will greatly ease the task of comparing results from more than 25 diagnostic tests for autism, by creating clusters of the various symptoms measured.

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Cognition and behavior: SHANK1 mutant mice do not model autism

by  /  25 October 2010

SHANK1 — a member of a family of proteins linked to autism — does not cause autism-like social deficits when mutated in mice, according to a study published online in September in Brain Research.

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Researchers probe linguistic patterns of Williams syndrome

by  /  25 October 2010

Children with Williams syndrome are chatty, have rich vocabularies and love to tell stories. Yet they have trouble learning certain complex rules of grammar, according to a study published in the Journal of Speech, Language and Hearing Research.

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Genetics: Sibling study delivers new autism candidates

by  /  22 October 2010

People with autism show differences in the levels of various gene products compared with their unaffected siblings, according to a study published online in September in Brain Research.

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Cancer protein directs synapse formation, study shows

by  /  21 October 2010

A tumor suppressor best known for its role in colorectal cancer plays a critical role in forming connections between neurons, according to a study in the August 18 issue of the Journal of Neuroscience.

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Genetics: New statistical analysis links mutations to disease

by  /  20 October 2010

A new study, published in September in PLOS Genetics, shows the importance of comparing cases to controls when linking mutations to a disorder. The researchers propose a new method of analysis that takes into account the large size of many genes expressed in the brain.

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