Skip to main content

Spectrum: Autism Research News

TOPIC

Genes

Rare or common, inherited or spontaneous, mutations form the core of autism risk.

June 2010

Faulty connectivity found in mouse model of schizophrenia

by  /  18 June 2010

Mice engineered to carry a well-known risk factor for schizophrenia show disruptions in the connections between two brain regions that coordinate memory and learning. And these disruptions directly cause problems with working memory — the ability to actively hold information and to recall that information to make a decision, according to a study published in Nature.

0 Comments

Rett gene function extends beyond neurons, study finds

by  /  15 June 2010

Microglia, brain cells that provide immune protection to neurons, may influence the onset and course of Rett syndrome, according to a study published in the Journal of Neuroscience.

0 Comments

Worms set to fill holes in autism research

by  /  14 June 2010

Worms, despite their crude nervous system, can be useful models of the genetic underpinnings of autism, according to unpublished work presented today at a meeting of the Genetics Society of America in Boston.

0 Comments

Autism marked by copy number changes in coding regions

by  /  11 June 2010

People with autism harbor more copy number variants (CNVs) — deletions or duplications of large chunks of DNA — compared with controls, but only in the protein-coding regions of the genome, researchers reported Wednesday in Nature. The study also pinpointed more than 100 new risk genes for autism.

1 Comment

New model mines simpler organisms for autism genes

by  /  3 June 2010

A new model that compares how the same genes behave in different organisms could help researchers identify previously unknown candidates for diseases such as autism. The model, published in the Proceedings of the National Academy of Sciences, takes advantage of the genetic overlap between humans and simpler organisms to discover genes associated with complex diseases.

0 Comments

Researchers identify biological roles for fragile X protein

by  /  1 June 2010

FMRP, the protein missing in fragile X syndrome, is needed for the birth of new neurons, for regulating the translation of RNA into protein, and for maintaining the structural integrity of spiny neuronal projections, according to several new studies.

0 Comments
May 2010

Microarray analysis deemed best genetic test for autism

by  /  28 May 2010

Chromosomal microarray analysis, which screens the entire genome for tiny blips in the sequence, should be the first genetic test performed when diagnosing autism, says a consortium of clinical geneticists. The recommendation comes on the heels of a study that found the test is three times more effective at spotting autism variants than are standard clinical methods.

5 Comments

Darwinian emotion

by  /  27 May 2010

Charles Darwin performed what may be the world’s first study of how people interpret and understand the emotions of others, according to a paper published in the Journal of the History of the Neurosciences.

0 Comments

Gene expression pattern could pinpoint autism

by  /  25 May 2010

Researchers can reliably identify individuals with autism by looking at the expression pattern of a set of genes in cultured blood cells, according to a poster presented Friday at the IMFAR 2010 conference in Philadelphia.

0 Comments

Children with autism and siblings share brain ‘signature’

by  /  24 May 2010

Children who have autism and their healthy siblings share patterns of brain activity that are different than those seen in children with no family history of the disorder, according to unpublished research presented at the IMFAR 2010 conference in Philadelphia.

1 Comment