Mutations in CHD8 lead to brain overgrowth or undergrowth in mice, depending on how they affect the gene’s expression.
Spectrum: Autism Research News
Rare or common, inherited or spontaneous, mutations form the core of autism risk.
There is not yet a single example of a gene that, when mutated, increases the likelihood of autism but not of other neurodevelopmental conditions, including intellectual disability.
A typically protective stress response could help to explain the connection between maternal illness and neurodevelopmental conditions.
Researchers have devised a way to use fluorescent sensors to detect many different signaling molecules in a cell at once.
People with fragile X syndrome in Colombia are diagnosed at age 27, on average, according to the first study to assess diagnosis in the country. By comparison, the average age of fragile X diagnosis in the United States is younger than 4.
Some neurons activate autism-linked genes when they fire, according to a new study.
Altering a protein linked to Rett syndrome so that it cannot bind to a methylation tag in neurons results in Rett-like traits in mice.
Blood levels of PTEN protein and associated molecules could eventually help diagnose autism and other neurological conditions — and predict their outcomes.